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腹腔镜结肠切除术与开腹结肠切除术相比,术后并发症发生率更低:一项倾向评分匹配队列分析。

Laparoscopic colectomy is associated with a lower incidence of postoperative complications than open colectomy: a propensity score-matched cohort analysis.

作者信息

Wilson M Z, Hollenbeak C S, Stewart D B

机构信息

Department of Surgery, College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania, USA.

出版信息

Colorectal Dis. 2014 May;16(5):382-9. doi: 10.1111/codi.12537.

Abstract

AIM

Elective laparoscopic colectomy (LC) has been shown to provide short-term results comparable with open colectomy (OC), but there is potential selection bias whereby LC patients may be healthier and therefore more likely to have a superior outcome. The aim of this study was to compare the incidence of postoperative complications between matched laparoscopic and open colectomy cohorts, while controlling for differences in comorbidity.

METHOD

A retrospective cohort study (2005-2010) using National Surgical Quality Improvement Program data was performed, identifying laparoscopic and open partial colectomy patients through common procedural terminology codes. Patient having rectal resection were excluded. The cohorts were matched 1:1 on a propensity score to control for observable selection bias due to patient characteristics, comparing overall complication rates, length of hospital stay (LOS), the incidence of superficial (S-SSI) surgical site infection, urinary tract infection (UTI) and deep-venous thrombosis (DVT).

RESULTS

We analysed 37 249 patients. After propensity score matching the LC group had a significantly lower overall incidence of postoperative complications (29.1 vs 21.2%; P < 0.0001), S-SSI (9.0 vs 5.9%; P = 0.003) and DVT (1.2 vs 0.3%; P = 0.001). The LC group had a shorter LOS (8.7 vs 6.4 days; P < 0.0001), while mortality was comparable between the two groups (4.0 vs 4.1%; P = 0.578).

CONCLUSION

LC is associated with a lower incidence of S-SSI and DVT than OC. Previously suggested advantages for laparoscopy, such as shorter length of stay and overall rate of complications, were observed even after controlling for differences in comorbidity.

摘要

目的

择期腹腔镜结肠切除术(LC)已被证明能提供与开腹结肠切除术(OC)相当的短期效果,但存在潜在的选择偏倚,即LC患者可能更健康,因此更有可能获得更好的结果。本研究的目的是比较匹配的腹腔镜和开腹结肠切除队列术后并发症的发生率,同时控制合并症的差异。

方法

利用国家外科质量改进计划数据进行了一项回顾性队列研究(2005 - 2010年),通过通用程序术语代码识别腹腔镜和开腹部分结肠切除术患者。排除接受直肠切除术的患者。根据倾向评分将队列1:1匹配,以控制因患者特征导致的可观察到的选择偏倚,比较总体并发症发生率、住院时间(LOS)、浅表手术部位感染(S-SSI)、尿路感染(UTI)和深静脉血栓形成(DVT)的发生率。

结果

我们分析了37249例患者。倾向评分匹配后,LC组术后并发症的总体发生率显著更低(29.1%对21.2%;P < 0.0001),S-SSI(9.0%对5.9%;P = 0.003)和DVT(1.2%对0.3%;P = 0.001)。LC组的LOS更短(8.7天对6.4天;P < 0.0001),而两组之间的死亡率相当(4.0%对4.1%;P = 0.578)。

结论

与OC相比,LC与S-SSI和DVT的发生率更低相关。即使在控制合并症差异后,之前提到的腹腔镜手术的优势,如住院时间更短和总体并发症发生率更低,仍然存在。

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