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Plasminogen activator inhibitor-1 in sputum and nasal lavage fluids increases in asthmatic patients during common colds.

作者信息

Cho Seong H, Hong Seung J, Chen Haimei, Habib Ali, Cho David, Lee Sun H, Kang Joseph, Ward Theresa, Boushey Homer A, Schleimer Robert P, Avila Pedro C

机构信息

Division of Allergy-Immunology, Department of Medicine, Northwestern Feinberg School of Medicine, Chicago, Ill; Division of Rheumatology, Department of Medicine, Kyung Hee University School of Medicine, Seoul, Korea.

Division of Allergy-Immunology, Department of Medicine, Northwestern Feinberg School of Medicine, Chicago, Ill; Division of Rheumatology, Department of Medicine, Kyung Hee University School of Medicine, Seoul, Korea.

出版信息

J Allergy Clin Immunol. 2014 May;133(5):1465-7, 1467.e1-2. doi: 10.1016/j.jaci.2013.11.009. Epub 2013 Dec 24.

DOI:10.1016/j.jaci.2013.11.009
PMID:24373352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4004714/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165a/7112324/9d87750ea0a3/fx2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165a/7112324/85820e661a77/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165a/7112324/cae876643cc0/fx1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165a/7112324/9d87750ea0a3/fx2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165a/7112324/85820e661a77/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165a/7112324/cae876643cc0/fx1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165a/7112324/9d87750ea0a3/fx2_lrg.jpg

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本文引用的文献

1
Exacerbations of severe asthma.严重哮喘恶化。
Clin Exp Allergy. 2012 May;42(5):670-7. doi: 10.1111/j.1365-2222.2012.03981.x.
2
A plasminogen activator inhibitor-1 inhibitor reduces airway remodeling in a murine model of chronic asthma.纤溶酶原激活物抑制剂-1 抑制剂可减少慢性哮喘小鼠模型中的气道重塑。
Am J Respir Cell Mol Biol. 2012 Jun;46(6):842-6. doi: 10.1165/rcmb.2011-0369OC. Epub 2012 Feb 9.
3
Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice.
纤溶酶原激活物抑制剂-1功能获得性基因型、增加纤溶酶原激活物抑制剂-1水平的因素与气道阻塞：GALA II队列研究
Clin Exp Allergy. 2017 Sep;47(9):1150-1158. doi: 10.1111/cea.12958. Epub 2017 Jul 3.
4
Association of a PAI-1 Gene Polymorphism and Early Life Infections with Asthma Risk, Exacerbations, and Reduced Lung Function.纤溶酶原激活物抑制剂-1（PAI-1）基因多态性及早期感染与哮喘风险、病情加重和肺功能降低的关联
PLoS One. 2016 Aug 24;11(8):e0157848. doi: 10.1371/journal.pone.0157848. eCollection 2016.
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TGF-β1-induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis.转化生长因子-β1诱导的纤溶酶原激活物抑制因子-1促成嗜酸性食管炎患者的促纤维化网络。
J Allergy Clin Immunol. 2016 Sep;138(3):791-800.e4. doi: 10.1016/j.jaci.2016.02.028. Epub 2016 Apr 8.
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Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma.纤溶酶原激活物抑制剂口服有效小分子抑制剂对哮喘的治疗潜力
Am J Physiol Lung Cell Mol Physiol. 2016 Feb 15;310(4):L328-36. doi: 10.1152/ajplung.00217.2015. Epub 2015 Dec 23.
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Am J Physiol Lung Cell Mol Physiol. 2011 Dec;301(6):L908-16. doi: 10.1152/ajplung.00115.2011. Epub 2011 Sep 16.
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Ann Allergy Asthma Immunol. 2011 May;106(5):371-7. doi: 10.1016/j.anai.2010.12.021. Epub 2011 Jan 26.
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New human rhinovirus species and their significance in asthma exacerbation and airway remodeling.新型人类鼻病毒及其在哮喘加重和气道重塑中的意义。
Immunol Allergy Clin North Am. 2010 Nov;30(4):541-52, vii. doi: 10.1016/j.iac.2010.08.007. Epub 2010 Sep 24.
6
Plasminogen activator inhibitor-1 and asthma: role in the pathogenesis and molecular regulation.纤溶酶原激活物抑制剂-1与哮喘：在发病机制及分子调控中的作用
Clin Exp Allergy. 2009 Aug;39(8):1136-44. doi: 10.1111/j.1365-2222.2009.03272.x. Epub 2009 May 5.
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Pan-viral screening of respiratory tract infections in adults with and without asthma reveals unexpected human coronavirus and human rhinovirus diversity.对有和没有哮喘的成人呼吸道感染进行全病毒筛查，发现了出人意料的人类冠状病毒和人类鼻病毒多样性。
J Infect Dis. 2007 Sep 15;196(6):817-25. doi: 10.1086/520816. Epub 2007 Aug 6.
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The -675 4G/5G plasminogen activator inhibitor-1 promoter polymorphism in house dust mite-sensitive allergic asthma patients.屋尘螨敏感型过敏性哮喘患者中纤溶酶原激活物抑制剂-1启动子-675 4G/5G多态性
Allergy. 2006 Feb;61(2):234-8. doi: 10.1111/j.1398-9995.2005.00948.x.
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Production of plasminogen activator inhibitor-1 by human mast cells and its possible role in asthma.人肥大细胞产生纤溶酶原激活物抑制剂-1及其在哮喘中的可能作用。
J Immunol. 2000 Sep 15;165(6):3154-61. doi: 10.4049/jimmunol.165.6.3154.
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Asthma and natural colds. Inflammatory indices in induced sputum: a feasibility study.哮喘与普通感冒。诱导痰中的炎症指标：一项可行性研究。
Am J Respir Crit Care Med. 1998 Oct;158(4):1178-84. doi: 10.1164/ajrccm.158.4.9712082.