Department of Surgery P, Aarhus University Hospital, Aarhus, Denmark.
Colorectal Dis. 2014 Jul;16(7):O223-33. doi: 10.1111/codi.12551.
Advances in the treatment of rectal cancer have made it possible to perform complex rectal cancer surgery (COMP-RCS) in patients with primary advanced rectal cancer penetrating beyond the total mesorectal excision planes and in patients with locally recurrent rectal cancer. The aim of this study was to examine health-related quality of life (HRQoL) before and during the first 2 years after COMP-RCS.
Between 2001 and 2008, 180 patients were treated with COMP-RCS at Aarhus University Hospital. HRQoL was assessed preoperatively and 3, 6, 12, 18 and 24 months after surgery using three questionnaires. The results were compared with those for patients treated with standard rectal cancer surgery (STAN-RCS) and with data from the general Danish population (NORM-data).
One hundred and twenty-two (68%) patients responded to the questionnaires. Of these 80 (66%) with disease-free survival for 2 years after surgery were included in the main analysis. The lowest level of functioning and the highest degree of symptoms were reported preoperatively. The majority of the HRQoL scales improved or remained stable during the first postoperative year; a decrease was observed for body image only. One year after surgery, HRQoL in patients treated with COMP-RSC was comparable to that for patients treated with STAN-RCS. Lower levels were found for physical and emotional role functioning, compared with NORM-data.
Patients treated with COMP-RCS experienced improvement in HRQoL in the first year after surgery. One year after surgery, HRQoL was similar to that of patients treated with STAN-RCS. Compared with NORM-data, lower levels were found for physical and emotional role functioning.
直肠癌治疗的进展使得对原发性局部晚期直肠癌穿透全直肠系膜切除平面的患者以及局部复发性直肠癌患者施行复杂直肠癌手术（COMP-RCS）成为可能。本研究旨在检测 COMP-RCS 术后前 2 年的健康相关生活质量（HRQoL）。
2001 年至 2008 年，阿乌斯大学医院对 180 例患者施行 COMP-RCS。术前及术后 3、6、12、18 和 24 个月采用 3 个问卷评估 HRQoL。结果与标准直肠癌手术（STAN-RCS）治疗的患者及丹麦一般人群（NORM-数据）进行比较。
122 例（68%）患者对问卷做出回应。其中 80 例（66%）术后 2 年无疾病生存患者被纳入主要分析。术前报告的功能状态最低，症状最严重。多数 HRQoL 量表在术后第 1 年改善或保持稳定；仅身体形象出现下降。术后 1 年，COMP-RCS 治疗的患者的 HRQoL 与 STAN-RCS 治疗的患者相似。与 NORM-数据相比，躯体和情感角色功能的水平较低。
COMP-RCS 治疗的患者在术后第 1 年 HRQoL 改善。术后 1 年，HRQoL 与 STAN-RCS 治疗的患者相似。与 NORM-数据相比，躯体和情感角色功能的水平较低。
