Department of Surgery P, Aarhus University Hospital, Aarhus, Denmark.
Colorectal Dis. 2012 Jul;14(7):797-803. doi: 10.1111/j.1463-1318.2011.02668.x.
Health-related quality of life is an important outcome measure in treatment of cancer. A review of the literature was undertaken to provide an overview of health-related quality of life (HRQoL) after surgery for primary advanced or recurrent rectal cancer and to outline proposals for future HRQoL studies in this area.
A systematic literature search was undertaken. Only studies concerning surgery for primary advanced or recurrent rectal cancer and describing methods used for measuring HRQoL were considered.
Seven studies were identified, including two prospective longitudinal studies, three cross-sectional studies and two based on qualitative data. Global quality of life, and physical, social, role and sexual function seemed to be impaired for a varying time after surgery. All the studies had methodical problems due to small sample size (12-44 patients) and different points of time for the assessment of HRQoL (12.3-47 months), which made it difficult to determine the period of time of impaired HRQoL and also if this is different after surgery for locally advanced or recurrent disease compared with after total mesorectal excision used for earlier tumours.
Several aspects of HRQoL are impaired for a variable time after treatment for locally advanced or recurrence of rectal cancer. Larger prospective longitudinal studies are needed to provide further information regarding the effects of this extensive surgery on quality of life.
健康相关生活质量是癌症治疗的重要结果衡量指标。本研究旨在综述原发性晚期或复发性直肠癌手术后的健康相关生活质量（HRQoL），并概述该领域未来 HRQoL 研究的建议。
进行了系统的文献检索。仅考虑了针对原发性晚期或复发性直肠癌手术并描述用于测量 HRQoL 的方法的研究。
确定了 7 项研究，包括 2 项前瞻性纵向研究、3 项横断面研究和 2 项基于定性数据的研究。全球生活质量以及身体、社会、角色和性功能似乎在手术后的不同时间受到损害。所有研究都由于样本量小（12-44 例患者）和 HRQoL 评估的不同时间点（12.3-47 个月）而存在方法学问题，这使得难以确定 HRQoL 受损的时间段，也难以确定局部晚期或复发性疾病手术后与用于早期肿瘤的全直肠系膜切除手术后的 HRQoL 是否不同。
在治疗局部晚期或直肠癌复发后，健康相关生活质量的多个方面在不同时间受到损害。需要进行更大规模的前瞻性纵向研究，以提供有关这种广泛手术对生活质量影响的进一步信息。
