Department of Chemistry, East China Normal University, Shanghai 200241, PR China.
Department of Chemistry, Yunnan Normal University, Kunming 650500, PR China.
J Chromatogr A. 2014 Jan 17;1325:163-70. doi: 10.1016/j.chroma.2013.12.023. Epub 2013 Dec 14.
This study focused on exploring the chromatographic characteristic of a homochiral MOF [Cu2(d-Cam)2(4,4'-bpy)]n with 3-D six-connected self-penetrating architectures for the separations of positional isomers and chiral compounds. Some effects such as mobile phase composition, column temperature, and analytes mass for separations on this chiral column also have been investigated. Among thirteen tested racemates, six compounds, namely three alcohols, a diol, a naphthol and a ketone were successfully discriminated, and ten useful positional isomers which have never been separated on other MOFs stationary phases in HPLC except dichlorobenzene and cresol isomers, were also analyzed by this chiral stationary phase. The results indicated that [Cu2(d-Cam)2(4,4'-bpy)]n exhibited good selectivity for positional isomers and enantiomers. Therefore, it is practicable that the separation of positional isomers and enantiomers are carried out on the chiral MOF column.
本研究专注于探索手性 MOF [Cu2(d-Cam)2(4,4'-bpy)]n 的色谱特性，该 MOF 具有 3-D 六连接自贯穿架构，可用于位置异构体和手性化合物的分离。还研究了分离过程中流动相组成、柱温、分析物质量等因素对这种手性柱的影响。在测试的 13 个外消旋体中，有 6 种化合物，即 3 种醇、1 种二醇、1 种萘酚和 1 种酮，成功地被分辨出来，此外，通过这种手性固定相还分析了 10 种除二氯苯和甲酚异构体之外，从未在手性 MOF 固定相上分离出过的有用位置异构体。结果表明，[Cu2(d-Cam)2(4,4'-bpy)]n 对位置异构体和对映体具有良好的选择性。因此，在手性 MOF 柱上进行位置异构体和对映体的分离是可行的。
