用于高效液相色谱对映体分离的3D同手性金属有机框架[Cd2(d-cam)3]•2Hdma•4dma
A 3D Homochiral MOF [Cd2(d-cam)3]•2Hdma•4dma for HPLC Chromatographic Enantioseparation.
作者信息
Zhang Mei, Chen Xinglian, Zhang Junhui, Kong Jiao, Yuan Liming
机构信息
Department of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming, P. R. China.
Agricultural Science Research Institute of Quality Standards and Testing Technology Institute of Yunnan Province, Kunming, P. R. China.
出版信息
Chirality. 2016 Apr;28(4):340-6. doi: 10.1002/chir.22588. Epub 2016 Feb 22.
Up to now, some chiral metal-organic frameworks (MOFs) have been reported for enantioseparation in liquid chromatography. Here we report a homochiral MOF, [Cd2(d-cam)3]·2Hdma·4dma, used as a new chiral stationary phase for high-performance liquid chromatographic enantioseparation. Nine racemates of alcohol, naphthol, ketone, and base compounds were used as analytes for evaluating the separation properties of the chiral MOF packed column. Moreover, some effects such as mobile phase composition, column temperature, and analytes mass for separations on this chiral column also were investigated. The relative standard deviations for the resolution values of run-to-run and column-to-column were less than 2.1% and 3.2%, respectively. The experimental results indicate that the homochiral MOF offered good recognition ability, which promotes the application of chiral MOFs use as stationary phase for enantioseparation.
到目前为止，已有一些手性金属有机框架材料（MOFs）被报道用于液相色谱中的对映体分离。在此，我们报道了一种纯手性MOF，[Cd2(d-cam)3]·2Hdma·4dma，用作高效液相色谱对映体分离的新型手性固定相。使用九种醇、萘酚、酮和碱化合物的外消旋体作为分析物，以评估填充有手性MOF的色谱柱的分离性能。此外，还研究了诸如流动相组成、柱温以及该手性柱上分离时分析物质量等一些影响因素。批内和柱间分离度值的相对标准偏差分别小于2.1%和3.2%。实验结果表明，该纯手性MOF具有良好的识别能力，这促进了手性MOFs作为对映体分离固定相的应用。
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