Lambrigger-Steiner C, Simões-Wüst A P, Kuck A, Fürer K, Hamburger M, von Mandach U
Department of Gynaecology and Obstetrics, Bülach Hospital, Bülach, Switzerland; Department of Obstetrics, Perinatal Pharmacology, Zurich University Hospital, Zurich, Switzerland.
Research Department, Paracelsus-Hospital Richterswil, Richterswil, Switzerland.
Phytomedicine. 2014 Apr 15;21(5):753-7. doi: 10.1016/j.phymed.2013.11.003. Epub 2013 Dec 25.
Poor sleep quality in pregnancy is frequent. A treatment with sedatives is problematic due to possible adverse effects for mother and embryo/foetus. In the present study, we investigated the sedative effect of Bryophyllum pinnatum, a phytotherapeutic medication used in anthroposophic medicine. In previous clinical studies on its tocolytic effect, B. pinnatum showed a good risk/benefit ratio for mother and child. A recent analysis of the prescribing pattern for B. pinnatum in a network of anthroposophic physicians revealed sleep disorders as one of the most frequent diagnoses for which these preparations are prescribed.
In this prospective, multi-centre, observational study, pregnant women suffering from sleep problems were treated with B. pinnatum (350mg tablets, 50% leaf press juice, Weleda AG, Arlesheim, dosage at physician's consideration). Sleep quality, daily sleepiness and fatigue were assessed with the aid of standardised questionnaires, at the beginning of the treatment and after 2 weeks. Possible adverse drug reactions perceived by the patients during the treatment were recorded.
The number of wake-ups, as well as the subjective quality of sleep was significantly improved at the end of the treatment with B. pinnatum. The Epworth Sleeping Scale decreased, indicating a decrease of the tiredness during the day. There was, however, no evidence for prolongation of the sleep duration, reduction in the time to fall asleep, as well as change in the Fatigue Severity Scale after B. pinnatum. No serious adverse drug reactions were detected.
B. pinnatum is a suitable treatment of sleep problems in pregnancy. The data of this study encourage further clinical investigations on the use of B. pinnatum in sleep disorders.
孕期睡眠质量差很常见。由于可能对母亲和胚胎/胎儿产生不良反应，使用镇静剂进行治疗存在问题。在本研究中，我们调查了落地生根的镇静作用，这是一种用于人智医学的植物疗法药物。在先前关于其宫缩抑制作用的临床研究中，落地生根对母婴显示出良好的风险/效益比。最近对人智医学医生网络中落地生根的处方模式分析显示，睡眠障碍是这些制剂最常被处方治疗的诊断之一。
在这项前瞻性、多中心、观察性研究中，患有睡眠问题的孕妇接受了落地生根治疗（350毫克片剂，50%叶压榨汁，Weleda AG，阿尔斯海姆，剂量由医生酌情决定）。在治疗开始时和2周后，借助标准化问卷评估睡眠质量、每日嗜睡和疲劳情况。记录患者在治疗期间可能察觉到的药物不良反应。
使用落地生根治疗结束时，夜间醒来次数以及睡眠主观质量均有显著改善。爱泼华嗜睡量表得分降低，表明白天疲劳感减轻。然而，没有证据表明落地生根治疗后睡眠时间延长、入睡时间缩短以及疲劳严重程度量表有变化。未检测到严重的药物不良反应。
落地生根是孕期睡眠问题的合适治疗方法。本研究数据鼓励对落地生根用于睡眠障碍的情况进行进一步临床研究。
