Gantner Giulia, Spiess Deborah, Randecker Eliane, Quack Lötscher Katharina C, Simões-Wüst Ana Paula
Department of Obstetrics, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Front Pharmacol. 2021 Oct 8;12:729724. doi: 10.3389/fphar.2021.729724. eCollection 2021.
Little is known about the treatment of mild mental disorders and/or symptoms (MDS) during pregnancy. Our main purpose was to compare the use of herbal medicines during pregnancy in women with and without MDS. A questionnaire consisting of 21 multiple-choice questions was distributed in the participating obstetrics clinics or birth centers in the Canton of Zurich, in Switzerland, from August 2018 to March 2019; 398 questionnaires were considered in the analysis. The use of any type of herbal medicines-including pharmaceutical herbal products as well as teas-during pregnancy was reported by 358 women (out of 398, 89.9%). Of these, 272 participants used pharmaceutical herbal products, whereby ginger (49.2%), raspberry leaf (42.7%), bryophyllum (37.8%), chamomile (27.2%), lavender (22%) and iron-rich herbs (12.3%) were the ones most commonly mentioned. More than half (207/398, 52.0%) of all participants reported suffering from MDS during pregnancy; only a few took (synthetic) psychoactive medications (5/398, 1.3%). The percentage of use of pharmaceutical herbal medicines was higher among women reporting MDS than among the remaining women (90.0 vs 75.9%; < 0.001). At the same time, the prevalence of MDS was higher among users of pharmaceutical herbal products than among non-users (59.6 vs 34.0%; = 0.001). Specific questions on candidate herbal medicines for the treatment of mild MDS revealed that bryophyllum (mentioned by 107 women), lavender (56 women) and valerian (20 women) were used to reduce stress, restlessness, sleep disorders and others, in part with perceived good to very good effectiveness and tolerability. The large majority of the pregnant women participating in the survey make use of herbal medicines. The particularly high prevalence of MDS among herbal medicine-users and the very rare use of synthetic psychoactive medications suggest that pregnant women rely on herbal medicines for treatment of mild MDS. The reported good effectiveness and tolerability of a few candidate herbal medicines deserve particular attention.
关于孕期轻度精神障碍和/或症状（MDS）的治疗，目前所知甚少。我们的主要目的是比较患有和未患有MDS的孕妇在孕期使用草药的情况。2018年8月至2019年3月期间，在瑞士苏黎世州参与调查的产科诊所或分娩中心发放了一份包含21个多项选择题的问卷；分析时纳入了398份问卷。358名女性（398名中的89.9%）报告在孕期使用过任何类型的草药，包括药用草药产品和茶。其中，272名参与者使用了药用草药产品，最常提及的有生姜（49.2%）、覆盆子叶（42.7%）、落地生根（37.8%）、洋甘菊（27.2%）、薰衣草（22%）和富含铁的草药（12.3%）。超过一半（207/398，52.0%）的参与者报告在孕期患有MDS；只有少数人服用（合成）精神活性药物（5/398，1.3%）。报告患有MDS的女性中，药用草药的使用比例高于其余女性（90.0%对75.9%；<0.001）。同时，药用草药产品使用者中MDS的患病率高于非使用者（59.6%对34.0%；=0.001）。关于治疗轻度MDS的候选草药的具体问题显示，落地生根（107名女性提及）、薰衣草（56名女性提及）和缬草（20名女性提及）被用于减轻压力、烦躁、睡眠障碍等，部分人认为效果良好至非常好且耐受性良好。参与调查的大多数孕妇都使用草药。草药使用者中MDS的患病率特别高，而合成精神活性药物的使用非常罕见，这表明孕妇依靠草药来治疗轻度MDS。少数候选草药报告的良好有效性和耐受性值得特别关注。
