Simões-Wüst Ana Paula, Hassani Taziri Al, Müller-Hübenthal Boris, Pittl Sandra, Kuck Angela, Meden Harald, Eberhard Jutta, Decker Michael, Fürer Karin, von Mandach Ursula
Paracelsus-Hospital Richterswil, Richterswil, Switzerland Clinic Arlesheim, Arlesheim, Switzerland
Paracelsus-Hospital Richterswil, Richterswil, Switzerland.
Integr Cancer Ther. 2015 Sep;14(5):452-9. doi: 10.1177/1534735415580680. Epub 2015 Apr 14.
Cancer patients frequently suffer from poor sleep quality. Bryophyllum pinnatum is a herbal medication used in anthroposophic medicine, which has been shown to be associated with improvements in sleep quality during pregnancy with only few and minor or moderate side-effects reported. In this study, the sleep quality of cancer patients during treatment with B pinnatum was investigated.
In this prospective, observational study, cancer patients suffering from sleep problems were treated with B pinnatum (350 mg tablets, corresponding to 50% of leaf pressed juice [Weleda AG, Arlesheim, Switzerland], dosage at physician's consideration, but most frequently 2 tablets with evening meal and 2 before going to bed).
Sleep quality (Pittsburgh Sleep Quality Index [PSQI]), daily sleepiness (Epworth Sleeping Scale [ESS]), and fatigue (Fatigue Severity Scale [FSS]) were assessed at the beginning of the treatment and after 3 weeks. Possible adverse drug reactions perceived by the patients during the treatment were recorded. From the 28 recruited patients, 20 completed both questionnaires and were considered in the present analysis. Data are expressed as mean ± standard deviation.
Patients were 61 ± 10.4 years old and the majority were female (17 out of 20). During treatment with B pinnatum, the PSQI decreased from 12.2 ± 3.62 to 9.1 ± 3.61 (P < .01), and ESS changed from 8.4 ± 3.18 to 7.1 ± 3.98 (P < .05). There was no change in FSS. The treatment was well tolerated by the majority of patients, with only 6 patients reporting discomfort that might have been caused by B pinnatum (fatigue n = 3, dry throat n = 1, agitation n = 1, difficult digestion n = 1). No serious adverse drug reactions were detected.
B pinnatum may be a suitable treatment for sleep problems of cancer patients. Controlled, randomized clinical trials of the use of B pinnatum in sleep disorders are urgently needed.
癌症患者经常睡眠质量不佳。落地生根是顺势疗法中使用的一种草药，已显示其与孕期睡眠质量改善有关，且仅有少数轻微或中度副作用的报告。在本研究中，对癌症患者在使用落地生根治疗期间的睡眠质量进行了调查。
在这项前瞻性观察研究中，对有睡眠问题的癌症患者使用落地生根进行治疗（350毫克片剂，相当于50%的叶压榨汁[瑞士阿尔勒的维蕾德公司]，剂量由医生决定，但最常见的是晚餐时服用2片，睡前服用2片）。
在治疗开始时和3周后评估睡眠质量（匹兹堡睡眠质量指数[PSQI]）、每日嗜睡程度（爱泼华嗜睡量表[ESS]）和疲劳程度（疲劳严重程度量表[FSS]）。记录患者在治疗期间可能察觉到的药物不良反应。在招募的28名患者中，20名完成了两份问卷并纳入本分析。数据以平均值±标准差表示。
患者年龄为61±10.4岁，大多数为女性（20名中有17名）。在使用落地生根治疗期间，PSQI从12.2±3.62降至9.1±3.61（P<.01），ESS从8.4±3.18变为7.1±3.98（P<.05）。FSS没有变化。大多数患者对治疗耐受性良好，只有6名患者报告了可能由落地生根引起的不适（疲劳3例，喉咙干1例，烦躁1例，消化不良1例）。未检测到严重的药物不良反应。
落地生根可能是治疗癌症患者睡眠问题的合适药物。迫切需要对落地生根用于睡眠障碍进行对照、随机临床试验。
