Gut Health & Food Safety Research Programme, Institute of Food Research, Norwich, UK.
Gut Health & Food Safety Research Programme, Institute of Food Research, Norwich, UK; Norwich Medical School, University of East Anglia, Norwich, UK.
Mech Ageing Dev. 2014 Mar-Apr;136-137:116-28. doi: 10.1016/j.mad.2013.12.003. Epub 2013 Dec 25.
Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly.
衰老是指随着感染和慢性疾病的发生频率增加，免疫功能逐渐衰退，免疫衰老的特征。这一复杂过程会影响先天和适应性免疫系统，导致大多数免疫细胞群体逐渐减少，激活缺陷，从而丧失功能。尽管宿主遗传和环境因素（如压力、运动和饮食）会影响免疫衰老的发生或进程，但涉及的机制在很大程度上尚不清楚。本综述重点介绍了确定免疫衰老的最重要方面的证据，以及营养干预可能延缓这一过程，从而提高老年人生活质量的证据。
