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衰老过程中的营养与生活方式管理:一项叙述性综述

Nutritional and lifestyle management of the aging journey: A narrative review.

作者信息

Kassis Amira, Fichot Marie-Claire, Horcajada Marie-Noelle, Horstman Astrid M H, Duncan Peter, Bergonzelli Gabriela, Preitner Nicolas, Zimmermann Diane, Bosco Nabil, Vidal Karine, Donato-Capel Laurence

机构信息

Whiteboard Nutrition Science, Beaconsfield, QC, Canada.

Nestlé Research, Société des Produits Nestlé S.A., Lausanne, Switzerland.

出版信息

Front Nutr. 2023 Jan 24;9:1087505. doi: 10.3389/fnut.2022.1087505. eCollection 2022.

Abstract

With age, the physiological responses to occasional or regular stressors from a broad range of functions tend to change and adjust at a different pace and restoring these functions in the normal healthy range becomes increasingly challenging. Even if this natural decline is somehow unavoidable, opportunities exist to slow down and attenuate the impact of advancing age on major physiological processes which, when weakened, constitute the hallmarks of aging. This narrative review revisits the current knowledge related to the aging process and its impact on key metabolic functions including immune, digestive, nervous, musculoskeletal, and cardiovascular functions; and revisits insights into the important biological targets that could inspire effective strategies to promote healthy aging.

摘要

随着年龄的增长,身体对各种功能偶尔或经常出现的应激源的生理反应往往会以不同的速度发生变化和调整,将这些功能恢复到正常健康范围变得越来越具有挑战性。即使这种自然衰退在某种程度上是不可避免的,但仍有机会减缓并减轻衰老对主要生理过程的影响,而这些生理过程一旦减弱,就构成了衰老的特征。这篇叙述性综述重新审视了与衰老过程及其对关键代谢功能(包括免疫、消化、神经、肌肉骨骼和心血管功能)的影响相关的现有知识;并重新审视了对重要生物学靶点的见解,这些见解可能会激发促进健康衰老的有效策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bf4/9903079/2f4063c8baba/fnut-09-1087505-g001.jpg

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