Internal Medicine Department, Columbia University at Harlem Hospital Center, 506 Lenox Avenue, MLK 14-106, New York, NY 10037, USA.
Internal Medicine Department, Columbia University at Harlem Hospital Center, 506 Lenox Avenue, MLK 14-106, New York, NY 10037, USA.
Heart Lung. 2014 Mar-Apr;43(2):117-9. doi: 10.1016/j.hrtlng.2013.11.009. Epub 2013 Dec 26.
3, 4-methylenedioxymethamphetamine (MDMA), popularly known as "ecstasy" is a synthetic, psychoactive drug used recreationally for its euphoric and "energy increasing" effects. MDMA has been linked to several severe adverse effects including the development of serotonin syndrome and sudden death. Individuals of Asian descent have been shown to have a predisposition for these severe adverse effects. We present a case of a young Asian-American male who following MDMA ingestion presented with severe rhabdomyolysis (CK 130,350 U/L), multiple organ failure and severe serotonin syndrome with one of the highest recorded temperatures '108.9 °F (42.7 °C)' in a survivor of severe serotonin syndrome. The patient initially received supportive care including ventilatory support; he eventually needed hemodialysis, but went on to make a full recovery within 3 weeks. This case shows and emphasizes the importance of 'aggressive' supportive care on patient prognosis particularly for patients on the extreme end of the serotonin syndrome.
3,4-亚甲二氧基甲基苯丙胺（MDMA），俗称“摇头丸”，是一种合成的、具有致幻作用的药物，因其欣快和“增加能量”的作用而被娱乐性使用。MDMA 与几种严重的不良反应有关，包括血清素综合征的发展和突然死亡。已经表明，亚洲血统的人更容易出现这些严重的不良反应。我们报告了一例年轻的亚裔美国男性，在服用摇头丸后出现严重的横纹肌溶解症（CK 130350 U/L）、多器官衰竭和严重的血清素综合征，其中记录的最高体温为 108.9°F（42.7°C），是严重血清素综合征幸存者中的一例。患者最初接受了包括通气支持在内的支持性治疗；他最终需要血液透析，但在 3 周内完全康复。这个病例表明并强调了“积极”的支持性治疗对患者预后的重要性，特别是对处于血清素综合征极端的患者。
