双功能硫代唾液酸抑制流感病毒。
Bifunctional thiosialosides inhibit influenza virus.
机构信息
788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States.
788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States.
出版信息
Bioorg Med Chem Lett. 2014 Jan 15;24(2):636-43. doi: 10.1016/j.bmcl.2013.11.077. Epub 2013 Dec 11.
Abstract
We have synthesized a panel of bivalent S-sialoside analogues, with modifications at the 4 position, as inhibitors of influenza virus. These first generation compounds show IC50 values ranging from low micromolar to high nanomolar in enzyme inhibition and plaque reduction assays with two intact viruses, Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68).
摘要
我们合成了一系列二价 S-唾液酸类似物作为流感病毒抑制剂，这些化合物在 4 位进行了修饰。在酶抑制和蚀斑减少试验中，这第一代化合物对两种完整的病毒，即甲型 H1N1（A/California/07/2009）和 H3N2（A/Hongkong/8/68），具有低至中微摩尔到高纳摩尔的 IC50 值。
相似文献
1
Bifunctional thiosialosides inhibit influenza virus.双功能硫代唾液酸抑制流感病毒。
Bioorg Med Chem Lett. 2014 Jan 15;24(2):636-43. doi: 10.1016/j.bmcl.2013.11.077. Epub 2013 Dec 11.
2
Sialic acid-mimic peptides as hemagglutinin inhibitors for anti-influenza therapy.唾液酸模拟肽作为抗流感治疗的血凝素抑制剂。
J Med Chem. 2010 Jun 10;53(11):4441-9. doi: 10.1021/jm1002183.
3
Synthesis and biological evaluation of sialic acid derivatives containing a long hydrophobic chain at the anomeric position and their C-5 linked polymers as potent influenza virus inhibitors.在糖环的端基位置引入长疏水链的唾液酸衍生物及其 C-5 连接聚合物的合成与生物评价作为有效的流感病毒抑制剂。
Bioorg Med Chem. 2012 Jan 1;20(1):446-54. doi: 10.1016/j.bmc.2011.10.064. Epub 2011 Oct 26.
4
Antiviral activity of novel oseltamivir derivatives against some influenza virus strains.新型奥司他韦衍生物对某些流感病毒株的抗病毒活性。
Acta Biochim Pol. 2014;61(3):509-13. Epub 2014 Sep 12.
5
Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents.新型 6-甲基-7-取代-7-脱氮嘌呤核苷类似物的设计、合成及体外生物评价作为抗流感 A 药物。
Antiviral Res. 2016 May;129:13-20. doi: 10.1016/j.antiviral.2016.01.005. Epub 2016 Jan 21.
6
New adamantane derivatives can overcome resistance of influenza A(H1N1)pdm2009 and A(H3N2) viruses to remantadine.新型金刚烷衍生物可克服甲型H1N1pdm2009流感病毒和甲型H3N2流感病毒对金刚乙胺的耐药性。
Bull Exp Biol Med. 2012 Jun;153(2):233-5. doi: 10.1007/s10517-012-1684-x.
7
Anti-influenza A Virus Activity of Dendrobine and Its Mechanism of Action.铁皮石斛素抗甲型流感病毒作用及其机制研究。
J Agric Food Chem. 2017 May 10;65(18):3665-3674. doi: 10.1021/acs.jafc.7b00276. Epub 2017 Apr 26.
8
Receptor tyrosine kinase inhibitors that block replication of influenza a and other viruses.阻断流感病毒和其他病毒复制的受体酪氨酸激酶抑制剂。
Antimicrob Agents Chemother. 2011 Dec;55(12):5553-9. doi: 10.1128/AAC.00725-11. Epub 2011 Sep 19.
9
Antiviral Activity of the Human Cathelicidin, LL-37, and Derived Peptides on Seasonal and Pandemic Influenza A Viruses.人源杀菌肽LL-37及其衍生肽对季节性和大流行性甲型流感病毒的抗病毒活性
PLoS One. 2015 Apr 24;10(4):e0124706. doi: 10.1371/journal.pone.0124706. eCollection 2015.
10
Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry.槲皮素作为一种抗病毒剂可抑制甲型流感病毒（IAV）的侵入。
Viruses. 2015 Dec 25;8(1):6. doi: 10.3390/v8010006.
引用本文的文献
1
Highly specific and rapid glycan based amperometric detection of influenza viruses.基于聚糖的流感病毒高特异性快速安培检测法
Chem Sci. 2017 May 1;8(5):3628-3634. doi: 10.1039/c6sc03720h. Epub 2017 Feb 14.
2
Electrochemical assay to detect influenza viruses and measure drug susceptibility.用于检测流感病毒和测定药物敏感性的电化学检测法。
Angew Chem Int Ed Engl. 2015 May 11;54(20):5929-32. doi: 10.1002/anie.201412164. Epub 2015 Mar 30.
3
Glycan based detection and drug susceptibility of influenza virus.基于聚糖的流感病毒检测与药敏性
Anal Chem. 2014 Aug 19;86(16):8238-44. doi: 10.1021/ac501624v. Epub 2014 Aug 1.
本文引用的文献
1
Oseltamivir resistance during treatment of H7N9 infection.H7N9感染治疗期间的奥司他韦耐药性。
Lancet. 2013 Jun 29;381(9885):2230-2. doi: 10.1016/S0140-6736(13)61209-X.
2
Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity.基于机制的共价神经氨酸酶抑制剂具有广谱抗流感病毒活性。
Science. 2013 Apr 5;340(6128):71-5. doi: 10.1126/science.1232552. Epub 2013 Feb 21.
3
Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors.流感神经氨酸酶通过亲核机制发挥作用，可被共价抑制剂靶向。
Nat Commun. 2013;4:1491. doi: 10.1038/ncomms2487.
4
Mucin biopolymers as broad-spectrum antiviral agents.粘蛋白生物聚合物作为广谱抗病毒药物。
Biomacromolecules. 2012 Jun 11;13(6):1724-32. doi: 10.1021/bm3001292. Epub 2012 May 21.
5
6
Systematic syntheses of influenza neuraminidase inhibitors: a series of carbosilane dendrimers uniformly functionalized with thioglycoside-type sialic acid moieties.流感神经氨酸酶抑制剂的系统合成：一系列用硫代糖苷型唾液酸部分均匀官能化的碳硅烷树枝状大分子。
Bioorg Med Chem. 2009 Aug 1;17(15):5451-64. doi: 10.1016/j.bmc.2009.06.036. Epub 2009 Jun 21.
7
Multiple components contribute to ability of saliva to inhibit influenza viruses.多种成分共同作用，使唾液具有抑制流感病毒的能力。
Oral Microbiol Immunol. 2009 Feb;24(1):18-24. doi: 10.1111/j.1399-302X.2008.00468.x.
8
Chemoenzymatic synthesis, characterization, and application of glycopolymers carrying lactosamine repeats as entry inhibitors against influenza virus infection.携带乳糖胺重复序列的糖聚合物作为流感病毒感染进入抑制剂的化学酶法合成、表征及应用
Glycobiology. 2008 Oct;18(10):779-88. doi: 10.1093/glycob/cwn067. Epub 2008 Jul 11.
9
Detection of intact influenza viruses using biotinylated biantennary S-sialosides.使用生物素化双触角 S-唾液酸苷检测完整流感病毒
J Am Chem Soc. 2008 Jul 2;130(26):8169-71. doi: 10.1021/ja800842v. Epub 2008 Jun 5.
10
The war against influenza: discovery and development of sialidase inhibitors.对抗流感之战：唾液酸酶抑制剂的发现与研发
Nat Rev Drug Discov. 2007 Dec;6(12):967-74. doi: 10.1038/nrd2400.
Zotero 插件