788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States.
788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States.
Bioorg Med Chem Lett. 2014 Jan 15;24(2):636-43. doi: 10.1016/j.bmcl.2013.11.077. Epub 2013 Dec 11.
We have synthesized a panel of bivalent S-sialoside analogues, with modifications at the 4 position, as inhibitors of influenza virus. These first generation compounds show IC50 values ranging from low micromolar to high nanomolar in enzyme inhibition and plaque reduction assays with two intact viruses, Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68).
我们合成了一系列二价 S-唾液酸类似物作为流感病毒抑制剂，这些化合物在 4 位进行了修饰。在酶抑制和蚀斑减少试验中，这第一代化合物对两种完整的病毒，即甲型 H1N1（A/California/07/2009）和 H3N2（A/Hongkong/8/68），具有低至中微摩尔到高纳摩尔的 IC50 值。
