Fernández Macarena, Fabio María Carolina, Nizhnikov Michael E, Spear Norman E, Abate Paula, Pautassi Ricardo Marcos
Instituto de Investigación Médica M. y M. Ferreyra, INIMEC-CONICET, Universidad Nacional de Córdoba, Córdoba, C.P., 5000, Argentina; Facultad de Psicología, Universidad Nacional de Córdoba, Córdoba, C.P., 5000, Argentina.
Dev Psychobiol. 2014 Jul;56(5):1070-82. doi: 10.1002/dev.21192. Epub 2013 Dec 24.
Animals exposed to chronic maternal separation (MS) exhibit enhanced ethanol self-administration and greater hormonal and behavioral responsiveness to stress in adulthood. Whether the effects of MS are immediately evident in infancy or whether they appear only later on development is still an unanswered question This study tested sensitivity to ethanol's behavioral stimulating effects in infant rats that experienced MS from postnatal Day 1-14. MS infants exhibited significantly greater reactivity to the motor stimulating effects of 1.25 g/kg ethanol than control animals, yet greater motor suppression after 2.5 g/kg ethanol. Baseline level of response to novelty was altered in MS infants, in a nor-binaltorphimine insensitive manner, that is, despite modified activity of the kappa-opioid system. These results indicate that the consequences of chronic maternal isolation emerge early in ontogeny, affecting ethanol sensitivity in infancy.
经历长期母婴分离（MS）的动物在成年后表现出乙醇自我给药增加，以及对应激的激素和行为反应增强。MS的影响在婴儿期是否立即显现，还是仅在后期发育中出现，仍是一个未解决的问题。本研究测试了从出生后第1天到第14天经历MS的幼鼠对乙醇行为刺激作用的敏感性。与对照动物相比，MS幼鼠对1.25 g/kg乙醇的运动刺激作用表现出明显更高的反应性，但在2.5 g/kg乙醇后运动抑制更强。MS幼鼠对新奇事物的基线反应水平以一种对纳洛酮不敏感的方式发生改变，即尽管κ-阿片系统的活性发生了改变。这些结果表明，长期母婴分离的后果在个体发育早期就已出现，影响婴儿期对乙醇的敏感性。
