Zhang Yunjian, Ren Ming, Li Jianhui, Wei Qian, Ren Zhixing, Lv Jingmao, Niu Fenglan, Ren Shuping
Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, China.
Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, China.
Environ Toxicol Pharmacol. 2014 Jan;37(1):284-90. doi: 10.1016/j.etap.2013.11.030. Epub 2013 Dec 12.
Persistent organic pollutant exposure is strongly associated with the development of diabetes. The development of diabetes or alteration in blood glucose levels is associated with insulin resistance that precedes diabetes for many years. Omethoate is a commonly used insecticide in most developing countries. The present study was designed to elucidate the potent role of omethoate in developing insulin resistance in rats. Male Wistar rats were exposed to omethoate at the concentration of 1.5mg/kg body weight (1/40 LD₅₀), 3 mg/kg body weight (1/20 LD₅₀) and 6 mg/kg body weight (1/10 LD₅₀) through gastric injection for 60 days; control group rats received PBS through gastric injection. The results showed that the levels of MDA, TNF-α and IL-6 were increased and the activities of SOD and GSH-Px were decreased in the right thigh muscles of rats exposed to omethoate. However, JNK, p38 MAPK and NF-κB in right thigh muscles of rats exposed to omethoate were activated. This study suggested that omethoate had a potential to cause insulin resistance.
持久性有机污染物暴露与糖尿病的发生密切相关。糖尿病的发生或血糖水平的改变与在糖尿病发生前数年就已存在的胰岛素抵抗有关。氧乐果是大多数发展中国家常用的一种杀虫剂。本研究旨在阐明氧乐果在大鼠胰岛素抵抗发生过程中的潜在作用。将雄性Wistar大鼠通过胃内注射给予浓度为1.5mg/kg体重（1/40 LD₅₀）、3mg/kg体重（1/20 LD₅₀）和6mg/kg体重（1/10 LD₅₀）的氧乐果，持续60天；对照组大鼠通过胃内注射给予PBS。结果显示，暴露于氧乐果的大鼠右大腿肌肉中丙二醛、肿瘤坏死因子-α和白细胞介素-6水平升高，超氧化物歧化酶和谷胱甘肽过氧化物酶活性降低。然而，暴露于氧乐果的大鼠右大腿肌肉中的JNK、p38丝裂原活化蛋白激酶和核因子-κB被激活。本研究表明氧乐果有导致胰岛素抵抗的潜在可能。
