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心理健康与精神障碍研究中对行为科学重点关注的必要性。

The need for a behavioural science focus in research on mental health and mental disorders.

作者信息

Wittchen Hans-Ulrich, Knappe Susanne, Andersson Gerhard, Araya Ricardo, Banos Rivera Rosa M, Barkham Michael, Bech Per, Beckers Tom, Berger Thomas, Berking Matthias, Berrocal Carmen, Botella Christina, Carlbring Per, Chouinard Guy, Colom Francesc, Csillag Claudio, Cujipers Pim, David Daniel, Emmelkamp Paul M G, Essau Cecilia A, Fava Giovanni A, Goschke Thomas, Hermans Dirk, Hofmann Stefan G, Lutz Wolfgang, Muris Peter, Ollendick Thomas H, Raes Filip, Rief Winfried, Riper Heleen, Tossani Eliana, van der Oord Saskia, Vervliet Bram, Haro Josep M, Schumann Gunter

机构信息

Institute of Clinical Psychology and Psychotherapy, Center for Clinical Epidemiology and Longitudinal Studies (CELOS), Technische Universität Dresden, Dresden, Germany.

出版信息

Int J Methods Psychiatr Res. 2014 Jan;23 Suppl 1(Suppl 1):28-40. doi: 10.1002/mpr.1409.

Abstract

Psychology as a science offers an enormous diversity of theories, principles, and methodological approaches to understand mental health, abnormal functions and behaviours and mental disorders. A selected overview of the scope, current topics as well as strength and gaps in Psychological Science may help to depict the advances needed to inform future research agendas specifically on mental health and mental disorders. From an integrative psychological perspective, most maladaptive health behaviours and mental disorders can be conceptualized as the result of developmental dysfunctions of psychological functions and processes as well as neurobiological and genetic processes that interact with the environment. The paper presents and discusses an integrative translational model, linking basic and experimental research with clinical research as well as population-based prospective-longitudinal studies. This model provides a conceptual framework to identify how individual vulnerabilities interact with environment over time, and promote critical behaviours that might act as proximal risk factors for ill-health and mental disorders. Within the models framework, such improved knowledge is also expected to better delineate targeted preventive and therapeutic interventions that prevent further escalation in early stages before the full disorder and further complications thereof develop. In contrast to conventional "personalized medicine" that typically targets individual (genetic) variation of patients who already have developed a disease to improve medical treatment, the proposed framework model, linked to a concerted funding programme of the "Science of Behaviour Change", carries the promise of improved diagnosis, treatment and prevention of health-risk behaviour constellations as well as mental disorders.

摘要

作为一门科学,心理学提供了多种多样的理论、原则和方法论来理解心理健康、异常功能与行为以及精神障碍。对心理科学的范围、当前主题以及优势与不足进行精选概述,可能有助于描绘出为指导未来特别是关于心理健康和精神障碍的研究议程所需的进展。从综合心理学的角度来看,大多数适应不良的健康行为和精神障碍可被概念化为心理功能与过程以及与环境相互作用的神经生物学和遗传过程发育功能失调的结果。本文介绍并讨论了一个综合转化模型,该模型将基础研究和实验研究与临床研究以及基于人群的前瞻性纵向研究联系起来。这个模型提供了一个概念框架,以确定个体脆弱性如何随时间与环境相互作用,并促进可能成为健康不良和精神障碍近端风险因素的关键行为。在该模型框架内,这样的知识改进也有望更好地勾勒出有针对性的预防和治疗干预措施,这些措施可在完全疾病及其进一步并发症发展之前的早期阶段预防病情进一步恶化。与传统的“个性化医疗”不同,传统“个性化医疗”通常针对已经患病的患者的个体(基因)变异以改善医疗治疗,而所提出的框架模型与“行为改变科学”的协同资助计划相关联,有望改善对健康风险行为组合以及精神障碍的诊断、治疗和预防。

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