脂质代谢对与年龄相关的认知衰退的影响：从模式生物和人类身上获得的经验教训。
The effect of lipid metabolism on age-associated cognitive decline: Lessons learned from model organisms and human.
作者信息
Wu Shihao, Liu Xiaoli, Yang Haiyan, Ma Wenlin, Qin Zhao
机构信息
Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Department of Geriatric Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
出版信息
IBRO Neurosci Rep. 2023 Sep 4;15:165-169. doi: 10.1016/j.ibneur.2023.08.2194. eCollection 2023 Dec.
Lipids are required as integral building blocks of cells to support cellular structures and functions. The intricate mechanisms underpinning lipid homeostasis are essential for the health and maintenance of the central nervous system. Here we summarize the recent advances in dissecting the effect of lipid metabolism on cognitive function and its age-associated decline by reviewing relevant studies ranging from invertebrate model organisms to mammals including human.
脂质是细胞不可或缺的组成部分，用于维持细胞结构和功能。支撑脂质稳态的复杂机制对于中枢神经系统的健康和维持至关重要。在此，我们通过回顾从无脊椎动物模型生物到包括人类在内的哺乳动物的相关研究，总结了剖析脂质代谢对认知功能及其与年龄相关衰退影响方面的最新进展。
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