Li Pengfei, Gao Yanyan, Ma Xiaojun, Zhou Shaobo, Guo Yujie, Xu Jingjing, Wang Xixiang, Van Halm-Lutterodt Nicholas, Yuan Linhong
School of Public Health, Capital Medical University, Beijing, China.
School of Life Sciences, Institute of Biomedical and Environmental Science and Technology, University of Bedfordshire, Luton, United Kingdom.
Front Aging Neurosci. 2022 Mar 31;14:846132. doi: 10.3389/fnagi.2022.846132. eCollection 2022.
The correlation between dietary fatty acid (FA) intake and serum lipid profile levels with cognition in the aged population has been reported by previous studies. However, the association of dietary FA intake and serum lipid profile levels with cognition in subjects with type 2 diabetes mellitus (T2DM) is seldom reported.
A cross-sectional study was conducted to explore the correlation between dietary FA intake and serum lipid profiles with cognition in the aged Chinese population with T2DM.
A total of 1,526 aged Chinese subjects were recruited from communities. Fasting blood samples were collected for parameter measurement. The food frequency questionnaire (FFQ) method was applied for a dietary survey. Cognition was assessed using the Montreal Cognitive Assessment (MoCA) test. Dietary FA intake and serum lipid levels were compared between subjects with T2DM and control subjects. A logistic regression analysis was carried out for analyzing the association of FA intake and serum lipid levels with the risk of mild cognitive impairment (MCI) in subjects with T2DM and control subjects.
There was a significant difference in the serum lipid level between the T2DM group and the control group. Results of the logistic regression analysis demonstrated the potential associations of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and dietary n-3 polyunsaturated fatty acids (PUFAs) intake with the risk of MCI in subjects with T2DM, but the associations were not observed in control subjects.
The T2DM phenotype might affect the relationship between dietary FA intake, circulating lipids, and cognitive performance. Large prospective cohort studies are needed to uncover the underlying mechanism of how dietary FA intake and serum lipid levels affect cognition in aged subjects with T2DM.
以往研究报道了老年人群饮食脂肪酸（FA）摄入量和血脂水平与认知之间的相关性。然而，关于2型糖尿病（T2DM）患者饮食FA摄入量和血脂水平与认知的关联鲜有报道。
开展一项横断面研究，探讨中国老年T2DM人群饮食FA摄入量和血脂水平与认知之间的相关性。
从社区招募了1526名中国老年受试者。采集空腹血样进行参数测量。采用食物频率问卷（FFQ）法进行饮食调查。使用蒙特利尔认知评估（MoCA）测试评估认知。比较T2DM患者和对照受试者的饮食FA摄入量和血脂水平。进行逻辑回归分析，以分析T2DM患者和对照受试者中FA摄入量和血脂水平与轻度认知障碍（MCI）风险的关联。
T2DM组和对照组的血脂水平存在显著差异。逻辑回归分析结果表明，血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-c）和饮食n-3多不饱和脂肪酸（PUFA）摄入量与T2DM患者的MCI风险存在潜在关联，但在对照受试者中未观察到这种关联。
T2DM表型可能影响饮食FA摄入量、循环血脂与认知表现之间的关系。需要开展大型前瞻性队列研究，以揭示饮食FA摄入量和血脂水平如何影响老年T2DM患者认知的潜在机制。
