Cameron Ivan L, Fullerton Gary D
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229-3900, USA.
Cell Biol Int. 2014 May;38(5):610-4. doi: 10.1002/cbin.10238. Epub 2014 Jan 30.
The osmotic responsiveness of cell water has been re-evaluated of reports on the osmotic behaviour of cells. In seven animal cell types, the osmotically unresponsive water (OUR) fraction values ranged from 0.75 to 2.41 g water/g dry mass (g/g), and from 25 to 92% of the total cell water. Protein confirmation, aggregation and crowding play a major, but under-recognised, role in determining the extent of OUR and the regulation of cell volume. Volume regulation studies that do not take into account the role of OUR must be judged incomplete.
细胞水的渗透反应性已根据有关细胞渗透行为的报告进行了重新评估。在七种动物细胞类型中，非渗透反应性水（OUR）的比例值范围为0.75至2.41克水/克干质量（g/g），占细胞总水量的25%至92%。蛋白质构象、聚集和拥挤在决定OUR的程度和细胞体积调节方面起着主要但未得到充分认识的作用。未考虑OUR作用的体积调节研究必须被判定为不完整。
