Zhang Zizhen, Bourque Charles W
Centre for Research in Neuroscience, Montreal General Hospital & McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada.
Nat Neurosci. 2003 Oct;6(10):1021-2. doi: 10.1038/nn1124. Epub 2003 Sep 14.
Mechanosensitive channels may act as osmosensory transducers because osmotically evoked changes in cell volume alter forces applied to the channel and affect opening probability. However, osmotically stimulated cells regulate volume normally, whereas systemic osmoregulatory responses are sustained. Here we report that osmosensory neurons of rat supraoptic nucleus expressed significant membrane reserves, and could not regulate volume or total membrane surface area during osmotic perturbations, which may allow mechanosensitive channels to encode the amplitude and time course of an osmotic stimulus.
机械敏感通道可能充当渗透感受器转导器，因为渗透引起的细胞体积变化会改变施加于通道的力并影响开放概率。然而，渗透刺激的细胞能正常调节体积，而全身渗透调节反应是持续的。我们在此报告，大鼠视上核的渗透感觉神经元表达了大量膜储备，并且在渗透扰动期间无法调节体积或总膜表面积，这可能使机械敏感通道能够编码渗透刺激的幅度和时程。
