Joehl R J
Pancreas. 1986;1(3):232-8. doi: 10.1097/00006676-198605000-00006.
This study was performed to characterize the inhibitory effects of terbutaline on pancreatic secretion. In experiments with pancreatic fistula dogs, intravenously administered terbutaline significantly reduced pancreatic juice volume, bicarbonate concentration, bicarbonate output, and protein output evoked by secretin or the octapeptide of cholecystokinin but had no effect on protein concentration. Subcutaneously administered terbutaline significantly reduced meal-stimulated pancreatic juice volume, bicarbonate concentration, bicarbonate output, and protein output and increased protein concentration in a dose-related manner. In other experiments, terbutaline had no effect on amylase release from dispersed guinea pig pancreatic acini. These observations suggest that the primary effect of terbutaline on the in vivo exocrine pancreas is inhibition of water and bicarbonate secretion; reduced output of pancreatic protein may be secondary to decreased flow of pancreatic juice.
本研究旨在表征特布他林对胰腺分泌的抑制作用。在胰腺瘘管犬实验中，静脉注射特布他林可显著降低由促胰液素或胆囊收缩素八肽诱发的胰液量、碳酸氢盐浓度、碳酸氢盐输出量和蛋白质输出量，但对蛋白质浓度无影响。皮下注射特布他林可显著降低餐食刺激引起的胰液量、碳酸氢盐浓度、碳酸氢盐输出量和蛋白质输出量，并以剂量相关的方式提高蛋白质浓度。在其他实验中，特布他林对分散的豚鼠胰腺腺泡淀粉酶释放无影响。这些观察结果表明，特布他林对体内外分泌胰腺的主要作用是抑制水和碳酸氢盐分泌；胰腺蛋白质输出量减少可能继发于胰液流量减少。
