Iijima F, Yamagishi F, Iwatsuki K, Kuroda T, Iida F, Chiba S
Jpn J Pharmacol. 1986 Apr;40(4):533-9. doi: 10.1254/jjp.40.533.
We examined the hypersecretory function of the isolated, blood-perfused pancreas of dogs with experimentally obstructive jaundice. There was no difference in basal pancreatic secretion between control dogs and obstructively jaundiced dogs. Secretin- or pancreozymin-stimulated increase in total values for pancreatic juice flow, bicarbonate, protein and amylase were greater in dogs with obstructive jaundice than in control dogs; however, concentrations of bicarbonate, protein and amylase were unchanged in each group. Acetylcholine-stimulated increase in total values and concentrations of these factors were the same in dogs with obstructive jaundice and controls. These data suggest that hypersensitivity of the pancreas to secretin and pancreozymin may be one of the main mechanisms of pancreatic hypersecretion.
我们研究了实验性梗阻性黄疸犬离体血液灌注胰腺的高分泌功能。对照犬和梗阻性黄疸犬的基础胰腺分泌无差异。在梗阻性黄疸犬中，促胰液素或胰酶泌素刺激引起的胰液流量、碳酸氢盐、蛋白质和淀粉酶总量的增加比对照犬更大；然而，每组中碳酸氢盐、蛋白质和淀粉酶的浓度没有变化。梗阻性黄疸犬和对照犬中，乙酰胆碱刺激引起的这些因子总量和浓度的增加是相同的。这些数据表明，胰腺对促胰液素和胰酶泌素的超敏反应可能是胰腺高分泌的主要机制之一。
