高氟牙膏对正畸治疗期间牙釉质脱矿的有效性——一项多中心随机对照试验

Effectiveness of high-fluoride toothpaste on enamel demineralization during orthodontic treatment-a multicenter randomized controlled trial.

作者信息

Sonesson Mikael, Twetman Svante, Bondemark Lars

机构信息

*Department of Orthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden and

**Department of Odontology, Section for Cariology & Endodontics and Pediatric Dentistry & Clinical Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

出版信息

Eur J Orthod. 2014 Dec;36(6):678-82. doi: 10.1093/ejo/cjt096. Epub 2013 Dec 28.

DOI:10.1093/ejo/cjt096

PMID:24375756

Abstract

OBJECTIVE

To evaluate the effectiveness of daily tooth brushing with high-fluoride toothpaste on white spot lesion (WSL) formation in adolescents during treatment with fixed orthodontic appliances (FOA).

MATERIALS AND METHODS

Four hundred and twenty-four healthy 11- to 16-year-old patients, referred to five Orthodontic Specialist Clinics, were randomized to use either toothpaste containing 5000 ppm fluoride or regular toothpaste with 1450 ppm fluoride. To be eligible for inclusion, the patients had to be scheduled for bimaxillary treatment with FOA for an expected duration of at least 1 year. The primary and secondary outcome measures were prevalence and incidence of WSL, as registered from digital photos of the maxillary incisors, canines, and premolars taken before onset and immediately after debonding. The photos were evaluated separately by two blinded and calibrated clinicians using a 4-step score. A random sample of 50 cases was reassessed to check intra- and interexaminer reliability (Kappa = 0.70; 0.74).

RESULTS

The use of high-fluoride toothpaste resulted in fewer WSL (P = 0.042) with a prevented fraction of 32%. The lateral incisor was most commonly affected in both groups.

CONCLUSION

To prevent WSL during treatment of FOA, daily use of high-fluoride toothpaste may be recommended.

摘要

目的

评估在青少年使用固定正畸矫治器（FOA）治疗期间，每天使用高氟牙膏刷牙对白斑病变（WSL）形成的有效性。

材料与方法

将转诊至五家正畸专科诊所的424名11至16岁健康患者随机分为两组，分别使用含5000 ppm氟化物的牙膏或含1450 ppm氟化物的普通牙膏。符合纳入条件的患者必须计划接受FOA的双颌治疗，预期持续时间至少为1年。主要和次要结局指标为WSL的患病率和发病率，通过在治疗开始前和拆除矫治器后立即拍摄的上颌切牙、尖牙和前磨牙的数码照片进行记录。由两名经过盲法校准的临床医生分别使用4级评分对照片进行评估。对50例病例的随机样本进行重新评估，以检查检查者内和检查者间的可靠性（Kappa = 0.70；0.74）。