Division of Pediatric Hematology-Oncology and Bone Marrow Transplantation, UH Rainbow Babies & Children's Hospital/Case Medical Center, Cleveland, Ohio.
Pediatr Blood Cancer. 2014 Jun;61(6):1124-5. doi: 10.1002/pbc.24906. Epub 2013 Dec 23.
To date ten sets of monozygotic twins with neuroblastoma have been reported in the literature. Twin-to-twin in utero metastasis have been proposed as the mechanism of tumor development in the second twin; based on similar pathology, presence of metastatic disease, absence of a primary tumor, and/or later presentation in the second twin. Hereditary neuroblastoma has not been described in this context. We propose that primary neuroblastoma can occur in monozygotic twins without twin-twin transmission; due to the different ages of presentation, histology, ploidy, and tumor behavior.
迄今为止，文献中已报道了十对患有神经母细胞瘤的同卵双胞胎。人们提出，双胞胎在子宫内的转移可能是第二个双胞胎肿瘤发展的机制；这一机制基于类似的病理学、转移性疾病的存在、原发性肿瘤的缺失，和/或第二个双胞胎较晚出现症状这一事实。在这种情况下，尚未描述遗传性神经母细胞瘤。我们提出，由于临床表现、组织学、倍性和肿瘤行为的不同，同卵双胞胎也可能发生原发性神经母细胞瘤，而无需通过双胞胎之间的传播。
