Boyd T K, Schofield D E
Children's Hospital, Boston, Massachusetts, USA.
Pediatr Pathol Lab Med. 1995 Nov-Dec;15(6):931-40. doi: 10.3109/15513819509027029.
To date, five sets of monozygotic twins concordant for neuroblastoma have appeared in the literature. Review of the clinical information available for these cases suggests that they represent congenital, versus acquired, diseases in both twins from each twin pair. The question arises, then, whether some or all sets of twins represent simultaneous-onset malignancy of both twins within a twin pair or whether metastasis via placental anastomoses from one twin with congenital disease to the cotwin occurs. This report includes a sixth set of monozygotic twins concordant for congenital neuroblastoma. From analysis of the clinical data from all cases, it appears that two of six twin pairs may represent simultaneous-onset tumors in each twin from a twin pair, and two of the remaining four twin pairs, including the present case, may represent placental metastases from one twin with congenital neuroblastoma to the other. In the remaining two twin pairs insufficient data are available upon which to draw any conclusions. Now that molecular and genetic methodology is available to characterize neuroblastomas, these techniques may be utilized in future cases of monozygotic twins concordant for congenital neuroblastoma, to help clarify whether the neoplasms represent simultaneous primary tumors versus metastatic spread from one twin to another.
迄今为止，文献中已出现五对患神经母细胞瘤的同卵双胞胎。对这些病例现有临床信息的回顾表明，每对双胞胎中的两个所患疾病均为先天性疾病，而非后天获得性疾病。于是问题就来了，部分或所有双胞胎病例究竟是代表双胞胎中两人同时发生恶性肿瘤，还是通过胎盘吻合从患有先天性疾病的一个双胞胎转移到另一个双胞胎身上。本报告包含第六对患先天性神经母细胞瘤的同卵双胞胎。通过对所有病例临床数据的分析，似乎六对双胞胎中有两对可能代表每对双胞胎中两人同时发病的肿瘤，其余四对中的两对，包括本病例，可能代表患有先天性神经母细胞瘤的一个双胞胎通过胎盘转移到另一个双胞胎身上。其余两对双胞胎缺乏足够数据来得出任何结论。鉴于现在已有分子和基因方法来对神经母细胞瘤进行特征描述，这些技术可用于未来患先天性神经母细胞瘤的同卵双胞胎病例，以帮助阐明这些肿瘤究竟是代表同时发生的原发性肿瘤，还是从一个双胞胎转移到另一个双胞胎的转移性扩散。
