聚酸酐/麻醉药纳米粒子的简便制备及其释放动力学的可调性。
Facile fabrication of polyanhydride/anesthetic nanoparticles with tunable release kinetics.
机构信息
Institute for Regenerative Engineering, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA; Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA; Department of Orthopaedic Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.
出版信息
Adv Healthc Mater. 2014 Jun;3(6):843-7. doi: 10.1002/adhm.201300521. Epub 2013 Dec 27.
Abstract
This work illustrates a two-step strategy for the fabrication of polymer/drug nanoparticles. Utilizing solvent/non-solvent precipitation and gaseous basification, composite nanoparticles with 0-100% drug loadings are fabricated. Drug release kinetics are dictated by nanoparticle composition allowing future tuning for therapeutic applications.
摘要
本工作说明了制备聚合物/药物纳米粒子的两步策略。利用溶剂/非溶剂沉淀和气体碱化作用，可以制备载药率为 0-100%的复合纳米粒子。药物释放动力学由纳米粒子的组成决定，这为治疗应用的进一步调整提供了可能。
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