Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (UK).
Angew Chem Int Ed Engl. 2014 Feb 3;53(6):1482-4. doi: 10.1002/anie.201308997. Epub 2013 Dec 27.
A means to trifluoromethylate: The beneficial properties imparted by the trifluoromethylation of aromatic compounds continue to drive the discovery of novel reagents and reactions for the late-stage introduction of such moieties. Highlighted here is the recently discovered Sandmeyer trifluoromethylation approach, which now permits aromatic amines to be substrates in a direct trifluoromethylation strategy.
芳香族化合物的三氟甲基化所赋予的有益性质继续推动着新型试剂和反应的发现，以实现这些基团的后期引入。这里重点介绍了最近发现的Sandmeyer 三氟甲基化方法，该方法现在可以使芳胺成为直接三氟甲基化策略中的底物。
