Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
J Am Chem Soc. 2010 Jun 2;132(21):7262-3. doi: 10.1021/ja102175w.
An efficient copper-mediated trifluoromethylation of terminal alkynes with nucleophilic trifluoromethylating reagent (Me(3)SiCF(3)) was developed. Both aromatic alkynes and aliphatic alkynes were effective, and a variety of functionalities such as amino, -OMe, -CO(2)Et, -Br, and -NO(2) were tolerated under the reaction conditions. This reaction provides a general, straightforward, and practically useful method to prepare trifluoromethylated acetylenes.
发展了一种高效的铜介导的末端炔烃与亲核三氟甲基化试剂（Me（3）SiCF3）的三氟甲基化反应。芳基炔烃和脂肪族炔烃都有效，并且在反应条件下可以容忍各种官能团，如氨基、-OMe、-CO（2）Et、-Br 和 -NO（2）。该反应提供了一种通用、直接、实用的方法来制备三氟甲基化的炔烃。
