铜介导的末端炔烃与 Me3SiCF3 的有氧三氟甲基化反应。
Copper-mediated aerobic oxidative trifluoromethylation of terminal alkynes with Me3SiCF3.
机构信息
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
出版信息
J Am Chem Soc. 2010 Jun 2;132(21):7262-3. doi: 10.1021/ja102175w.
An efficient copper-mediated trifluoromethylation of terminal alkynes with nucleophilic trifluoromethylating reagent (Me(3)SiCF(3)) was developed. Both aromatic alkynes and aliphatic alkynes were effective, and a variety of functionalities such as amino, -OMe, -CO(2)Et, -Br, and -NO(2) were tolerated under the reaction conditions. This reaction provides a general, straightforward, and practically useful method to prepare trifluoromethylated acetylenes.
发展了一种高效的铜介导的末端炔烃与亲核三氟甲基化试剂（Me（3）SiCF3）的三氟甲基化反应。芳基炔烃和脂肪族炔烃都有效，并且在反应条件下可以容忍各种官能团，如氨基、-OMe、-CO（2）Et、-Br 和 -NO（2）。该反应提供了一种通用、直接、实用的方法来制备三氟甲基化的炔烃。
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