Stefanidou S, Gerodimos C, Benos A, Galanopoulou V, Chatziyannis I, Kanakoudi F, Aslanidis S, Boura P, Sfetsios T, Settas L, Katsounaros M, Papadopoulou D, Giamalis P, Dombros N, Chatzistilianou M, Garyfallos A
4 Department of Internal Medicine, Aristotle University, Hippokration Hospital.
Department of Hygiene, Aristotle University.
Hippokratia. 2013 Apr;17(2):153-6.
To analyze the pattern of clinical expression and the 5-year disease course in Caucasian patients with late onset of systemic lupus erythematosus (SLE) and to compare the findings with an early onset SLE group.
Medical records of 551 patients who presented with SLE at hospitals of the region of Thessaloniki between 1989 and 2007 were studied. Patients who developed SLE at or after the age of 50 years were classified as the late onset group, while younger patients served as the early onset group. Data on clinical manifestations and damage accrual at disease onset and at 5 years was obtained and compared between the two groups.
In 121 patients, the disease started after the age of 50 years. Elderly patients showed less pronounced female predominance and less often presented with malar rash, nephropathy, fever and lymphadenopathy, while lung involvement, pericarditis and sicca syndrome were more frequent. Damage accrual was similar in both groups. The main causes of damage at 5 years differed, with the elderly exhibiting more cardiovascular damage. They also had a higher incidence of hypertension and osteoporosis at 5 years.
Caucasian SLE patients with late onset of the disease present with different clinical manifestations, suggesting that age affects the expression of SLE. Damage accrual at 5 years is similar in the elderly and the younger patients. However, the causes of this damage and the occurrence of other comorbidities follow a different pattern, possibly reflecting the disease process and the effects of aging.
分析白种人迟发性系统性红斑狼疮（SLE）患者的临床表型模式及5年病程，并将结果与早发性SLE组进行比较。
研究了1989年至2007年间在塞萨洛尼基地区医院就诊的551例SLE患者的病历。50岁及以后发病的患者被归类为迟发性组，而年轻患者作为早发性组。获取并比较两组患者疾病发作时和5年时的临床表现及损伤累积数据。
121例患者在50岁以后发病。老年患者女性优势不明显，较少出现颧部红斑、肾病、发热和淋巴结病，而肺部受累、心包炎和干燥综合征更为常见。两组的损伤累积情况相似。5年时损伤发生的主要原因不同，老年患者心血管损伤更多。他们在5年时高血压和骨质疏松的发生率也更高。
迟发性白种人SLE患者表现出不同的临床表现，提示年龄影响SLE的表现。老年患者和年轻患者5年时的损伤累积情况相似。然而，这种损伤的原因及其他合并症的发生遵循不同模式，可能反映了疾病进程和衰老的影响。
