Vincent van Gogh Institute for Psychiatry, Venlo, the Netherlands.
Department of Pharmacy, VieCuri Medical Centre, Venlo, the Netherlands.
Neuropsychiatr Dis Treat. 2014;10:13-8. doi: 10.2147/NDT.S53430. Epub 2013 Dec 10.
The aim of this retrospective study was to explore the relationship between psychotropic medication dosage and birth outcomes.
A total of 136 women were enrolled, who had an active mental disorder, were taking medication to prevent a relapse, or had a history of postpartum depression or psychosis. Medication use was evaluated for the three trimesters and during labor. Based on the defined daily dose, medication use was classified into three groups. Primary outcome variables included the infant gestational age at birth, birth weight, and Apgar scores at one and 5 minutes.
Our study showed a significantly higher incidence of Apgar score ≤7 at 5 minutes in women taking psychotropic drugs as compared with the group taking no medication, respectively (16.3% versus 0.0%, P=0.01). There was no significant difference between the two groups in Apgar score at one minute or in gestational age and birth weight. The results showed no significant differences in gestational age, birth weight, or Apgar scores for a low-intermediate or high dose of a selective serotonin reuptake inhibitor and for a low or intermediate dose of an antipsychotic.
This study does not indicate a relationship between doses of selective serotonin reuptake inhibitors and antipsychotics and adverse neonatal outcomes.
本回顾性研究旨在探讨精神药物剂量与生育结局之间的关系。
共纳入 136 名患有活跃精神障碍、正在服用预防复发药物或有产后抑郁或精神病病史的女性。评估了三个孕期和分娩期间的药物使用情况。根据规定的日剂量，将药物使用分为三组。主要结局变量包括婴儿出生时的胎龄、出生体重和 1 分钟及 5 分钟时的 Apgar 评分。
与未服用精神药物的女性相比，服用精神药物的女性在 5 分钟时的 Apgar 评分≤7 的发生率明显更高（16.3%与 0.0%，P=0.01）。两组在 1 分钟时的 Apgar 评分、胎龄和出生体重方面无显著差异。结果显示，低-中剂量选择性 5-羟色胺再摄取抑制剂和低或中剂量抗精神病药的剂量与新生儿不良结局之间无显著差异。
本研究表明，选择性 5-羟色胺再摄取抑制剂和抗精神病药的剂量与不良新生儿结局之间没有关系。
