超分割高剂量率近距离放射治疗口腔舌癌
Hyperfractionated high-dose rate brachytherapy in the treatment of oral tongue cancer.
作者信息
Tuček Lubos, Petera Jiri, Sirák Igor, Vošmik Milan, Doležalová Helena, Brokešová Simona, Hodek Miroslav, Kašaová Linda, Paluska Petr
机构信息
Department of Stomatology, University Hospital, Hradec Králové, Czech Republic.
Department of Oncology and Radiotherapy, University Hospital, Sokolská 581, 500 05 Hradec Králové, Czech Republic.
出版信息
Rep Pract Oncol Radiother. 2011 Aug 6;16(6):243-7. doi: 10.1016/j.rpor.2011.07.001. eCollection 2011.
BACKGROUND
Low-dose rate brachytherapy is a well established treatment modality of oral cancer. Data about high-dose rate (HDR) brachytherapy are still sparse with various fractionation schedules and heterogeneous results.
AIM
The aim of our retrospective study was to evaluate the results of HDR brachytherapy with doses of 3 Gy twice daily.
PATIENTS AND METHODS
Twenty patients with squamous cell tongue cancer were treated in the years 2001-2009 by exclusive HDR BT 18 × 3 Gy twice daily. The plastic tube technique was used. Median follow up was 47 months (7.8-118) since brachytherapy.
RESULTS
The local and locoregional control was 85% and 68%, respectively. Bone necrosis developed in one case treated without mandibular shielding and soft tissue necrosis in 2 cases.
CONCLUSION
It can be concluded that HDR brachytherapy with 18 × 3 Gy twice daily is safe with promising local control. The risk of nodal recurrences is substantial.
背景
低剂量率近距离放射治疗是口腔癌一种成熟的治疗方式。关于高剂量率（HDR）近距离放射治疗的数据仍然稀少，存在各种分割方案且结果各异。
目的
我们这项回顾性研究的目的是评估每天两次给予3 Gy剂量的高剂量率近距离放射治疗的效果。
患者与方法
2001年至2009年期间，20例舌鳞状细胞癌患者接受了单纯高剂量率近距离放射治疗，每天两次，每次18×3 Gy。采用塑料导管技术。自近距离放射治疗后，中位随访时间为47个月（7.8 - 118个月）。
结果
局部和区域控制率分别为85%和68%。1例未进行下颌屏蔽治疗的患者发生骨坏死，2例发生软组织坏死。
结论
可以得出结论，每天两次给予18×3 Gy的高剂量率近距离放射治疗是安全的，局部控制效果良好。淋巴结复发风险较高。
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