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Late nodal metastasis in early-stage node-negative oral cavity cancers after successful sole interstitial brachytherapy: an institutional experience of 42 cases in India.
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Efficacy of high-dose-rate interstitial brachytherapy in patients with oral tongue carcinoma.高剂量率组织间近距离放射疗法治疗口腔舌癌患者的疗效
Brachytherapy. 2010 Jul-Sep;9(3):227-34. doi: 10.1016/j.brachy.2009.10.003. Epub 2010 Jan 29.
3
Prediction of lymphatic metastasis based on gene expression profile analysis after brachytherapy for early-stage oral tongue carcinoma.基于早期口腔舌癌近距离放疗后基因表达谱分析的淋巴转移预测
Radiother Oncol. 2008 May;87(2):237-42. doi: 10.1016/j.radonc.2007.12.027. Epub 2008 Jan 25.
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Neck node metastasis after successful brachytherapy for early stage tongue carcinoma.早期舌癌近距离放射治疗成功后出现颈部淋巴结转移。
Radiother Oncol. 2003 Aug;68(2):129-35. doi: 10.1016/s0167-8140(03)00187-7.
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Brachytherapy for early oral tongue cancer: low dose rate to high dose rate.早期口腔舌癌的近距离放射治疗：从低剂量率到高剂量率
J Radiat Res. 2003 Mar;44(1):37-40. doi: 10.1269/jrr.44.37.
7
Phase III trial of high- vs. low-dose-rate interstitial radiotherapy for early mobile tongue cancer.
Int J Radiat Oncol Biol Phys. 2001 Sep 1;51(1):171-5. doi: 10.1016/s0360-3016(01)01561-9.
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The American Brachytherapy Society recommendations for high-dose-rate brachytherapy for head-and-neck carcinoma.美国近距离放射治疗学会关于头颈部癌高剂量率近距离放射治疗的建议。
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Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Nov;90(5):667-70. doi: 10.1067/moe.2000.110087.
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超分割高剂量率近距离放射治疗口腔舌癌

Hyperfractionated high-dose rate brachytherapy in the treatment of oral tongue cancer.

作者信息

Tuček Lubos, Petera Jiri, Sirák Igor, Vošmik Milan, Doležalová Helena, Brokešová Simona, Hodek Miroslav, Kašaová Linda, Paluska Petr

机构信息

Department of Stomatology, University Hospital, Hradec Králové, Czech Republic.

Department of Oncology and Radiotherapy, University Hospital, Sokolská 581, 500 05 Hradec Králové, Czech Republic.

出版信息

Rep Pract Oncol Radiother. 2011 Aug 6;16(6):243-7. doi: 10.1016/j.rpor.2011.07.001. eCollection 2011.

DOI:10.1016/j.rpor.2011.07.001
PMID:24376988
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3863239/
Abstract

BACKGROUND

Low-dose rate brachytherapy is a well established treatment modality of oral cancer. Data about high-dose rate (HDR) brachytherapy are still sparse with various fractionation schedules and heterogeneous results.

AIM

The aim of our retrospective study was to evaluate the results of HDR brachytherapy with doses of 3 Gy twice daily.

PATIENTS AND METHODS

Twenty patients with squamous cell tongue cancer were treated in the years 2001-2009 by exclusive HDR BT 18 × 3 Gy twice daily. The plastic tube technique was used. Median follow up was 47 months (7.8-118) since brachytherapy.

RESULTS

The local and locoregional control was 85% and 68%, respectively. Bone necrosis developed in one case treated without mandibular shielding and soft tissue necrosis in 2 cases.

CONCLUSION

It can be concluded that HDR brachytherapy with 18 × 3 Gy twice daily is safe with promising local control. The risk of nodal recurrences is substantial.

摘要

背景

低剂量率近距离放射治疗是口腔癌一种成熟的治疗方式。关于高剂量率（HDR）近距离放射治疗的数据仍然稀少，存在各种分割方案且结果各异。

目的

我们这项回顾性研究的目的是评估每天两次给予3 Gy剂量的高剂量率近距离放射治疗的效果。

患者与方法

2001年至2009年期间，20例舌鳞状细胞癌患者接受了单纯高剂量率近距离放射治疗，每天两次，每次18×3 Gy。采用塑料导管技术。自近距离放射治疗后，中位随访时间为47个月（7.8 - 118个月）。

结果

局部和区域控制率分别为85%和68%。1例未进行下颌屏蔽治疗的患者发生骨坏死，2例发生软组织坏死。

结论

可以得出结论，每天两次给予18×3 Gy的高剂量率近距离放射治疗是安全的，局部控制效果良好。淋巴结复发风险较高。