Zhu Wen-Wen, Kang Li, Gao Ya-Ping, Hei Yan, Dong Jie, Liu Yu, Xiao Li-Hua, Yang Guang
Medical College of Qingdao University, Qingdao, China E-mail :
Asian Pac J Cancer Prev. 2013;14(11):6439-43. doi: 10.7314/apjcp.2013.14.11.6439.
To investigate whether the expression level of valosin-containing protein (VCP) is correlated with the prognosis of primary orbital mucosa-associated lymphoid tissue (MALT) lymphoma.
VCP expression in 58 samples from primary orbital MALT lymphoma patients was determined by immunohistochemisty using monoclonal antibodies. Correlations between VCP expression level and prognosis were clarified by statistical analysis.
It was found that the percentage of VCP positive cells in samples of primary orbital MALT lymphoma ranged from 32% to 95%. The samples were divided into two groups (level 1 and level 2) according to the median value (45%) of the percentage of VCP positive cells. It was found that the expression level of VCP was significantly correlated with recurrence (P=0.003) and tumor size (P=0.008). At the same time, the 5-year disease-free and overall survival rate of patients of level 1 was significantly better than that of level 2 (P=0.001; P=0.032). There was no observed correlation between the expression level of VCP and other clinical features.
VCP could be a useful marker for predicting the prognosis of primary orbital MALT lymphoma.
探讨含缬酪肽蛋白（VCP）的表达水平与原发性眼眶黏膜相关淋巴组织（MALT）淋巴瘤预后是否相关。
采用单克隆抗体免疫组化法检测58例原发性眼眶MALT淋巴瘤患者样本中的VCP表达。通过统计分析明确VCP表达水平与预后的相关性。
发现原发性眼眶MALT淋巴瘤样本中VCP阳性细胞百分比为32%至95%。根据VCP阳性细胞百分比的中位数（45%）将样本分为两组（1级和2级）。发现VCP表达水平与复发（P=0.003）和肿瘤大小（P=0.008）显著相关。同时，1级患者的5年无病生存率和总生存率显著优于2级患者（P=0.001；P=0.03）。未观察到VCP表达水平与其他临床特征之间的相关性。
VCP可能是预测原发性眼眶MALT淋巴瘤预后的有用标志物。
