Yin Zhi-Hua, Cui Zhi-Gang, Ren Yang-Wu, Su Meng, Ma Rui, He Qin-Cheng, Zhou Bao-Sen
Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China E-mail :
Asian Pac J Cancer Prev. 2014 Jan;14(11):6519-22. doi: 10.7314/apjcp.2013.14.11.6519.
Genetic polymorphisms of TP63 have been suggested to influence susceptibility to lung adenocarcinoma development in East Asian populations. This study aimed to investigate the relationship between common polymorphisms in the TP63 gene and the risk of lung adenocarcinoma, as well as interactions of the polymorphisms with environmental risk factors in Chinese non-smoking females.
A case-control study of 260 cases and 318 controls was conducted. Data concerning demographic and risk factors were obtained for each subject. The genetic polymorphisms were determined by Taqman real-time PCR and statistical analyses were performed using SPSS software.
For 10937405, carriers of the CT genotype or at least one T allele (CT/TT) had lower risks of lung adenocarcinoma compared with the homozygous wild CC genotype in Chinese nonsmoking females (adjusted ORs were 0.68 and 0.69, 95%CIs were 0.48-0.97 and 0.50-0.97, P values were 0.033 and 0.030, respectively). Allele comparison showed that the T allele of rs10937405 was associated with a decreased risk of lung adenocarcinoma with an OR of 0.78 (95%CI=0.60-1.01, P=0.059). Our results showed that exposure to cooking oil fumes was associated with increased risk of lung adenocarcinoma in Chinese nonsmoking females (adjusted OR=1.58, 95%CI=1.11-2.25, P=0.011). However, we did not observe a significant interaction of cooking oil fumes and TP63 polymorphisms.
TP63 polymorphism might be a genetic susceptibility factor for lung adenocarcinoma in Chinese non-smoking females, but no significant interaction was found with cooking oil fume exposure.
有研究表明，TP63基因的遗传多态性会影响东亚人群患肺腺癌的易感性。本研究旨在调查TP63基因常见多态性与肺腺癌风险之间的关系，以及这些多态性与中国非吸烟女性环境危险因素之间的相互作用。
进行了一项包含260例病例和318例对照的病例对照研究。收集了每个研究对象的人口统计学和危险因素数据。通过Taqman实时荧光定量PCR检测基因多态性，并使用SPSS软件进行统计分析。
对于10937405位点，在中国非吸烟女性中，CT基因型携带者或至少携带一个T等位基因（CT/TT）的个体患肺腺癌的风险低于纯合野生型CC基因型个体（校正比值比分别为0.68和0.69，95%置信区间分别为0.48 - 0.97和0.50 - 0.97，P值分别为0.033和0.030）。等位基因比较显示，rs10937405的T等位基因与肺腺癌风险降低相关，比值比为0.78（95%置信区间 = 0.60 - 1.01，P = 0.059）。我们的研究结果表明，接触烹饪油烟与中国非吸烟女性患肺腺癌的风险增加相关（校正比值比 = 1.58，95%置信区间 = 1.11 - 2.25，P = 0.011）。然而，我们未观察到烹饪油烟与TP63基因多态性之间存在显著的相互作用。
TP63基因多态性可能是中国非吸烟女性患肺腺癌的遗传易感性因素，但未发现与烹饪油烟暴露存在显著相互作用。
