转化生长因子β-1（TGFβ-1）和转化生长因子β受体2（TGFBR2）基因多态性、烹饪油烟暴露与中国非吸烟女性肺腺癌风险：一项病例对照研究
TGFβ-1 and TGFBR2 polymorphisms, cooking oil fume exposure and risk of lung adenocarcinoma in Chinese nonsmoking females: a case control study.
作者信息
Ren Yangwu, Yin Zhihua, Li Kun, Wan Yan, Li Xuelian, Wu Wei, Guan Peng, Zhou Baosen
机构信息
Department of Epidemiology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China.
Liaoning Provincial Department of Education, Key Laboratory of Cancer Etiologic and Prevention (China Medical University), Liaoning, 110122, China.
出版信息
BMC Med Genet. 2015 Apr 10;16:22. doi: 10.1186/s12881-015-0170-5.
BACKGROUND
Transforming growth factor-β (TGF-β) plays an important role in regulating cellular functions, and many studies have demonstrated important roles for TGF-β in various cancers. Single nucleotide polymorphisms (SNPs) of TGF-β may influence lung carcinogenesis. The aim of this study was to test whether TGF-β1 C509T and TGF-β receptor II (TGFBR2) G-875A polymorphisms were associated with lung adenocarcinoma in nonsmoking females.
METHODS
A hospital-based case-control study was performed in Chinese nonsmoking females. Genotyping was performed using TaqMan SNP genotyping assay, and demographic data and environmental exposure were collected by trained interviewers after informed consents were obtained.
RESULTS
A total of 272 (95.4%) cases and 313 (99.4%) controls were successfully genotyped, and the results showed that the polymorphic allele frequencies of C509T and G875A were similar among lung adenocarcinoma patients and controls (P=0.589 and 0.643, respectively). However, when the data were stratified for cooking oil fume exposure, the TT genotype of the TGFB1 C509T polymorphism showed a significantly decreased risk for lung adenocarcinoma compared with the CC genotype (adjusted OR=0.362, 95% CI=0.149-0.878, P=0.025).
CONCLUSIONS
TGF-β1 gene C509T polymorphism might be associated with decreased risk of lung adenocarcinoma in Chinese females exposed to cooking oil fumes, but no association was observed TGFBR2 gene G875A polymorphism.
背景
转化生长因子-β（TGF-β）在调节细胞功能中起重要作用，许多研究已证明TGF-β在各种癌症中具有重要作用。TGF-β的单核苷酸多态性（SNP）可能影响肺癌发生。本研究的目的是检测TGF-β1 C509T和TGF-β受体II（TGFBR2）G-875A多态性是否与非吸烟女性的肺腺癌相关。
方法
在中国非吸烟女性中进行了一项基于医院的病例对照研究。使用TaqMan SNP基因分型测定法进行基因分型，在获得知情同意后，由经过培训的访谈员收集人口统计学数据和环境暴露情况。
结果
共成功对272例（95.4%）病例和313例（99.4%）对照进行了基因分型，结果显示肺腺癌患者和对照中C509T和G875A的多态性等位基因频率相似（P分别为0.589和0.643）。然而，当根据食用油烟雾暴露对数据进行分层时，与CC基因型相比，TGFB1 C509T多态性的TT基因型显示肺腺癌风险显著降低（校正OR=0.362，95%CI=0.149-0.878，P=0.025）。
结论
TGF-β1基因C509T多态性可能与接触食用油烟雾的中国女性肺腺癌风险降低相关，但未观察到TGFBR2基因G875A多态性与之相关。
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