Pandurangan Ashok Kumar, Ananda Sadagopan Suresh Kumar, Dharmalingam Prakash, Ganapasam Sudhandiran
Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India E-mail :
Asian Pac J Cancer Prev. 2014 Jan;14(11):6669-72. doi: 10.7314/apjcp.2013.14.11.6669.
Colon cancer (CRC) is a serious health problem throughout the world. Development of novel drugs without side effects for this cancer is crucial. Luteolin (LUT), a bioflavonoid, has many beneficial effects such as antioxidant, anti-inflammatory and anti-proliferative potential. was a potent chemical carcinogen used for the induction of colon cancer. Colon carcinogenesis was initiated by intraperitoneal injection of azoxymethane (AOM) to mice at the dose of 15 mg/body kg weight in Balb/C mice for 3 weeks. Mice were treated with LUT at the dose of 1.2 mg /body kg weight orally. Mitochondrial enzymes such as isocitrate dehydrogenase (ICDH), α-keto dehydrogenase (α-KDH), succinate dehydrogenase (SDH) and the activities of respiratory chain enzymes NADH dehydrogenase and cytochrome c oxidase were found to be elevated in AOM-treated animals. Treatment with LUT decreased the activities of all the parameters significantly. Hence, LUT might be a potent anticancer agent against colorectal cancer.
结肠癌（CRC）是全球范围内严重的健康问题。开发针对这种癌症且无副作用的新型药物至关重要。木犀草素（LUT）是一种生物类黄酮，具有许多有益作用，如抗氧化、抗炎和抗增殖潜力。偶氮甲烷（AOM）是一种强效化学致癌物，用于诱导结肠癌。通过以15mg/体重kg的剂量向Balb/C小鼠腹腔注射AOM持续3周来启动结肠癌发生。小鼠以1.2mg/体重kg的剂量口服LUT进行治疗。发现在经AOM处理的动物中，异柠檬酸脱氢酶（ICDH）、α-酮脱氢酶（α-KDH）、琥珀酸脱氢酶（SDH）等线粒体酶以及呼吸链酶NADH脱氢酶和细胞色素c氧化酶的活性升高。用LUT治疗可显著降低所有这些参数的活性。因此，LUT可能是一种针对结直肠癌的强效抗癌剂。
