高温对培养中的人体细胞、其对病毒的敏感性以及产生干扰素能力的影响。
The influence of high temperature on human cells in culture, their sensitivity to viruses and their interferon-producing capacity.
作者信息
Kognovitskaya A I, Bokhonko A I, Mamontova T V, Orlova T G
出版信息
Acta Virol. 1987 Jan;31(1):7-12.
The influence of extremely high temperatures on the course of virus infection in vitro was studied. It has been shown that exposure of human cells (continuous cell line of embryonal skin-muscle tissue, donor blood leukocytes) to 43 degrees C leads to a significant increase in their sensitivity to cytopathic action of the viruses tested. Noteworthy, the reproduction of these viruses under tested conditions did not differ from their reproduction in control cells. A dramatic inhibitory effect of high temperatures on the interferon-producing capacity of cells was observed.
研究了极高温度对体外病毒感染过程的影响。结果表明，将人类细胞（胚胎皮肤肌肉组织连续细胞系、供血者血液白细胞）暴露于43摄氏度会导致它们对所测试病毒的细胞病变作用的敏感性显著增加。值得注意的是，在测试条件下这些病毒的繁殖与它们在对照细胞中的繁殖没有差异。观察到高温对细胞产生干扰素的能力有显著的抑制作用。
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