Bigliardi Enrico, Bresciani Carla, Callegari Daniela, Di Ianni Francesco, Morini Giorgio, Parmigiani Enrico, Bianchi Ezio
Department of Veterinary Science, University of Parma, 43100 Parma,
J Vet Sci. 2014;15(2):267-71. doi: 10.4142/jvs.2014.15.2.267. Epub 2013 Dec 27.
Insulin resistance (IR) in dogs is suspected when hyperglycemia is present despite administration of insulin doses greater than 1.0 to 1.5 UI/kg. IR is caused by increases in counter regulatory hormones concentrations (glucagon, glucocorticoids, catecholamines and growth hormone). This study was conducted to investigate the use of aglepristone (RU 46534), a P4 receptor antagonist, for the treatment of IR diabetes mellitus in bitches during the luteal phase. All animals were treated with porcine insulin zinc suspension (Caninsulin) and aglepristone (Alizin) 10 mg/kg subcutaneously at day 1, 2, 9 and 17 from diagnosis. At day 5, no significant variation in glycemia was shown. At day 12 and 20, serum glucose concentrations were significant lower (p < 0.05). From day 12 the insulin dose was reduced to 0.8 IU BID. Insulin was reduced in the following weeks and glycemia was controlled.
当给予大于1.0至1.5 UI/kg的胰岛素剂量后仍出现高血糖时，怀疑犬存在胰岛素抵抗（IR）。IR是由对抗调节激素浓度（胰高血糖素、糖皮质激素、儿茶酚胺和生长激素）升高引起的。本研究旨在调查P4受体拮抗剂阿格列司酮（RU 46534）在黄体期用于治疗母犬IR糖尿病的效果。从诊断开始的第1、2、9和17天，所有动物均皮下注射猪胰岛素锌混悬液（甘精胰岛素）和10 mg/kg阿格列司酮（阿利辛）。在第5天，血糖无显著变化。在第12天和第20天，血清葡萄糖浓度显著降低（p < 0.05）。从第12天起，胰岛素剂量减至0.8 IU，每日两次。在接下来的几周内胰岛素剂量减少，血糖得到控制。
