参数化会影响群体模型的可识别性。
Parameterisation affects identifiability of population models.
机构信息
School of Pharmacy, University of Otago, P.O. Box 56, Dunedin, 9054, New Zealand,
出版信息
J Pharmacokinet Pharmacodyn. 2014 Feb;41(1):81-6. doi: 10.1007/s10928-013-9347-8. Epub 2013 Dec 31.
PMID:24378914
Abstract
Identifiability is an important aspect of model development. In this work, using a simple one compartment population pharmacokinetic model, we show that identifiability of the variances of the random effects parameters are affected by the parameterisation of the fixed effects parameters.
摘要
可识别性是模型开发的一个重要方面。在这项工作中，我们使用一个简单的单室群体药代动力学模型，表明随机效应参数的方差的可识别性受到固定效应参数参数化的影响。
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