日本溃疡性结肠炎发病的季节性变化。
Seasonal variations in the onset of ulcerative colitis in Japan.
机构信息
Shigeo Koido, Toshifumi Ohkusa, Kan Uchiyama, Hiroshi Arakawa, Hisao Tajiri, Division of Gastroenterology and Hepatology, Department of Internal Medicine, the Jikei University School of Medicine, Chiba 277-8567, Japan.
出版信息
World J Gastroenterol. 2013 Dec 21;19(47):9063-8. doi: 10.3748/wjg.v19.i47.9063.
AIM
To investigate seasonal variations in the onset and relapse of ulcerative colitis (UC) in Japanese patients.
METHODS
Between 1994 and 2006, 198 Japanese patients diagnosed with UC according to conventional criteria in an academic hospital were enrolled for onset evaluation. Among 265 Japanese patients with UC who were observed for more than 12 mo, 165 patients relapsed (239 times) and were enrolled for relapse evaluation. The patients' symptoms were recorded each month for 12 consecutive years.
RESULTS
There was monthly seasonality in symptom onset during October and March for UC. The onset of symptoms in UC patients frequently occurred during the winter. Variation in UC onset was observed according to both month (P = 0.015) and season (P = 0.048). Relapse commonly occurred in October, and variations in relapse were not significant either in month (P = 0.52) or season (P = 0.12). Upper respiratory inflammation was the main factor responsible for relapse.
CONCLUSION
Our results suggest that environmental factors associated with winter and spring seasonality may be responsible for triggering the clinical onset of UC in Japan.
目的
研究日本溃疡性结肠炎（UC）患者发病和复发的季节性变化。
方法
1994 年至 2006 年间，在一家学术医院根据传统标准诊断为 UC 的 198 例日本患者纳入发病评估。在观察时间超过 12 个月的 265 例 UC 日本患者中，165 例复发（239 次）并纳入复发评估。患者的症状每月连续记录 12 年。
结果
UC 患者的症状在 10 月和 3 月存在季节性发病。UC 患者的症状常发生在冬季。UC 发病的变化与月份（P = 0.015）和季节（P = 0.048）有关。复发常见于 10 月，复发的月份（P = 0.52）和季节（P = 0.12）差异无统计学意义。上呼吸道炎症是导致复发的主要因素。
结论
我们的结果表明，与冬季和春季季节性相关的环境因素可能导致日本 UC 的临床发病。
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