Moum B, Aadland E, Ekbom A, Vatn M H
Ostfold Sentralsykehus, Fredrikstad, Sweden.
Gut. 1996 Mar;38(3):376-8. doi: 10.1136/gut.38.3.376.
Several retrospective studies have reported seasonal variations in the relapse of ulcerative colitis, and two studies have found seasonality in the onset of ulcerative colitis, with a peak from August to January. This study was designed to investigate possible seasonal variations of onset of ulcerative colitis (UC) and Crohn's disease (CD). Patients with symptoms of one year or less were recruited from a prospective study of the incidence of inflammatory bowel disease, and the onset of symptoms was recorded month by month for four consecutive years. A total of 420 patients with UC and 142 patients with CD were included. There was monthly seasonality (p = 0.028) in symptomatic onset in December and January for UC but not for CD. It was found that environmental agents with known seasonality can be of importance for the seasonal variations of disease onset in UC.
多项回顾性研究报告了溃疡性结肠炎复发的季节性变化，两项研究发现溃疡性结肠炎发病存在季节性，8月至1月为发病高峰。本研究旨在调查溃疡性结肠炎（UC）和克罗恩病（CD）发病可能存在的季节性变化。从一项关于炎症性肠病发病率的前瞻性研究中招募症状出现一年以内的患者，并连续四年逐月记录症状出现的时间。共纳入420例UC患者和142例CD患者。UC患者在12月和1月的症状性发病存在月度季节性（p = 0.028），而CD患者则不存在。研究发现，具有已知季节性的环境因素可能对UC疾病发病的季节性变化具有重要影响。
