儿童病毒诱发的喘息/哮喘的流行病学
Epidemiology of virus-induced wheezing/asthma in children.
作者信息
Inoue Yuzaburo, Shimojo Naoki
机构信息
Department of Pediatrics, Graduate School of Medicine, Chiba University Chiba, Japan.
出版信息
Front Microbiol. 2013 Dec 16;4:391. doi: 10.3389/fmicb.2013.00391.
Abstract
Wheezing is a lower respiratory tract symptom induced by various viral respiratory infections. Epidemiological studies have revealed the phenotypes of wheezing in early childhood which have different risk factors for the development of asthma among school age children. The major viral species causing wheezing in children include respiratory syncytial virus, rhinovirus, human metapneumovirus and influenza viruses. It has been shown that the impact on the development of asthma is different between those virus species. Moreover, recent studies have also focused on the interaction between virus infection and other risk factors in the development of asthma, such as genetic factors or allergic sensitization. In this review, we summarize the previous findings and discuss how clinicians can effectively intervene in these viral infections to prevent the development of asthma.
摘要
喘息是由各种病毒性呼吸道感染引起的下呼吸道症状。流行病学研究揭示了儿童早期喘息的表型，这些表型在学龄儿童哮喘的发展中有不同的危险因素。引起儿童喘息的主要病毒种类包括呼吸道合胞病毒、鼻病毒、人偏肺病毒和流感病毒。已经表明，这些病毒种类对哮喘发展的影响是不同的。此外，最近的研究还关注病毒感染与哮喘发展中其他危险因素（如遗传因素或过敏致敏）之间的相互作用。在本综述中，我们总结了先前的研究结果，并讨论临床医生如何有效干预这些病毒感染以预防哮喘的发生。
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