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Genetic susceptibility to methylmercury developmental neurotoxicity matters.对甲基汞发育神经毒性的遗传易感性很重要。
Front Genet. 2013 Dec 13;4:278. doi: 10.3389/fgene.2013.00278. eCollection 2013.
2
Methylmercury and brain development: imprecision and underestimation of developmental neurotoxicity in humans.甲基汞与大脑发育：人类发育神经毒性的不精确性及低估情况
Mt Sinai J Med. 2011 Jan-Feb;78(1):107-18. doi: 10.1002/msj.20228.
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Overview of modifiers of methylmercury neurotoxicity: chemicals, nutrients, and the social environment.甲基汞神经毒性的修饰因素概述：化学物质、营养素及社会环境
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Human-induced pluripotent stems cells as a model to dissect the selective neurotoxicity of methylmercury.人诱导多能干细胞作为一种模型来剖析甲基汞的选择性神经毒性。
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A human pluripotent carcinoma stem cell-based model for in vitro developmental neurotoxicity testing: effects of methylmercury, lead and aluminum evaluated by gene expression studies.一种基于人多能癌干细胞的体外发育神经毒性测试模型：通过基因表达研究评估甲基汞、铅和铝的影响。
Int J Dev Neurosci. 2013 Nov;31(7):679-91. doi: 10.1016/j.ijdevneu.2013.03.002. Epub 2013 Mar 13.
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Adverse effects of methylmercury: environmental health research implications.甲基汞的不良反应：环境健康研究的启示。
Environ Health Perspect. 2010 Aug;118(8):1137-45. doi: 10.1289/ehp.0901757. Epub 2010 Jun 8.
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Neurobehavioral toxicity of methylmercury and PCBs Effects-profiles and sensitive populations.甲基汞和多氯联苯的神经行为毒性。作用特征和敏感人群。
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Methylmercury-induced neurotoxicity and apoptosis.甲基汞诱导的神经毒性和细胞凋亡。
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Methylmercury effects on ion channels and electrical activity in neurons: future directions.甲基汞对神经元离子通道和电活动的影响：未来方向
Cell Mol Biol (Noisy-le-grand). 2000 Jun;46(4):855-64.

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Identifying studies evaluating susceptibility factors for chemical health assessments: A case study focused on methylmercury developmental neurotoxicity.识别评估化学物质健康评估易感性因素的研究：以甲基汞发育神经毒性为例的案例研究。
Environ Int. 2025 Mar;197:109331. doi: 10.1016/j.envint.2025.109331. Epub 2025 Feb 15.
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Developmental exposure to methylmercury and ADHD, a literature review of epigenetic studies.发育过程中甲基汞暴露与注意缺陷多动障碍：表观遗传学研究的文献综述
Environ Epigenet. 2021 Nov 22;7(1):dvab014. doi: 10.1093/eep/dvab014. eCollection 2021.
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Environmentally relevant developmental methylmercury exposures alter neuronal differentiation in a human-induced pluripotent stem cell model.环境相关的发育性甲基汞暴露会改变人类诱导多能干细胞模型中的神经元分化。
Food Chem Toxicol. 2021 Jun;152:112178. doi: 10.1016/j.fct.2021.112178. Epub 2021 Apr 5.
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Mercury Exposure Assessment in Mother-Infant Pairs from Continental and Coastal Croatia.来自克罗地亚大陆和沿海地区母婴对的汞暴露评估。
Biomolecules. 2020 May 27;10(6):821. doi: 10.3390/biom10060821.
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A Birth Cohort Study on the Genetic Modification of the Association of Prenatal Methylmercury With Child Cognitive Development.一项基于出生队列的研究：探讨产前甲基汞与儿童认知发育关联的遗传修饰作用。
Am J Epidemiol. 2019 Oct 1;188(10):1784-1793. doi: 10.1093/aje/kwz156.
6
Human-induced pluripotent stems cells as a model to dissect the selective neurotoxicity of methylmercury.人诱导多能干细胞作为一种模型来剖析甲基汞的选择性神经毒性。
Biochim Biophys Acta Gen Subj. 2019 Dec;1863(12):129300. doi: 10.1016/j.bbagen.2019.02.002. Epub 2019 Feb 10.
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Exposure to Mercury in Workers and the Population Surrounding Gold Mining Areas in the Mojana Region, Colombia.哥伦比亚莫霍纳地区金矿周边地区工人和居民接触汞的情况。
Int J Environ Res Public Health. 2018 Oct 23;15(11):2337. doi: 10.3390/ijerph15112337.
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Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes.关于为监管目的开展发育神经毒性（DNT）测试，需要创新、转型和实施的共识声明。
Toxicol Appl Pharmacol. 2018 Sep 1;354:3-6. doi: 10.1016/j.taap.2018.02.004. Epub 2018 Feb 12.
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Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress.神经毒性与功能失调的金属离子动态平衡和外源性金属暴露有关：氧化还原信号和氧化应激。
Antioxid Redox Signal. 2018 Jun 20;28(18):1669-1703. doi: 10.1089/ars.2017.7272. Epub 2018 Mar 28.
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Methylmercury exposure causes a persistent inhibition of myogenin expression and C2C12 myoblast differentiation.甲基汞暴露会持续抑制肌细胞生成素的表达以及C2C12成肌细胞的分化。
Toxicology. 2018 Jan 15;393:113-122. doi: 10.1016/j.tox.2017.11.002. Epub 2017 Nov 15.

本文引用的文献

1
Modifying roles of glutathione S-transferase polymorphisms on the association between cumulative lead exposure and cognitive function.修饰谷胱甘肽 S-转移酶多态性在累积铅暴露与认知功能之间的关联中的作用。
Neurotoxicology. 2013 Dec;39:65-71. doi: 10.1016/j.neuro.2013.08.002. Epub 2013 Aug 16.
2
Prenatal methylmercury exposure and genetic predisposition to cognitive deficit at age 8 years.产前甲基汞暴露与 8 岁时认知缺陷的遗传易感性。
Epidemiology. 2013 Sep;24(5):643-50. doi: 10.1097/EDE.0b013e31829d5c93.
3
Modification of neurobehavioral effects of mercury by genetic polymorphisms of metallothionein in children.儿童中金属硫蛋白基因多态性对汞神经行为效应的影响
Neurotoxicol Teratol. 2013 Sep-Oct;39:36-44. doi: 10.1016/j.ntt.2013.06.004. Epub 2013 Jul 1.
4
Polymorphisms in glutathione-related genes modify mercury concentrations and antioxidant status in subjects environmentally exposed to methylmercury.环境甲基汞暴露人群中，谷胱甘肽相关基因多态性可改变汞浓度和抗氧化状态。
Sci Total Environ. 2013 Oct 1;463-464:319-25. doi: 10.1016/j.scitotenv.2013.06.029. Epub 2013 Jul 2.
5
Mercury, APOE, and children's neurodevelopment.汞、载脂蛋白 E 与儿童神经发育。
Neurotoxicology. 2013 Jul;37:85-92. doi: 10.1016/j.neuro.2013.03.012. Epub 2013 Apr 18.
6
Modification of neurobehavioral effects of mercury by a genetic polymorphism of coproporphyrinogen oxidase in children.儿童粪卟啉原氧化酶基因多态性对汞神经行为效应的修饰作用。
Neurotoxicol Teratol. 2012 Sep-Oct;34(5):513-21. doi: 10.1016/j.ntt.2012.06.004. Epub 2012 Jul 2.
7
An investigation of modifying effects of metallothionein single-nucleotide polymorphisms on the association between mercury exposure and biomarker levels.汞暴露与生物标志物水平之间关联的金属硫蛋白单核苷酸多态性修饰作用的研究。
Environ Health Perspect. 2012 Apr;120(4):530-4. doi: 10.1289/ehp.1104079. Epub 2012 Jan 9.
8
Relation between methylmercury exposure and plasma paraoxonase activity in inuit adults from Nunavik.努纳武特因纽特成年人甲基汞暴露与血浆对氧磷酶活性的关系。
Environ Health Perspect. 2011 Aug;119(8):1077-83. doi: 10.1289/ehp.1003296. Epub 2011 May 4.
9
Gene-environment interplay in common complex diseases: forging an integrative model—recommendations from an NIH workshop.常见复杂疾病中的基因-环境相互作用：构建一个综合模型——美国国立卫生研究院研讨会的建议
Genet Epidemiol. 2011 May;35(4):217-25. doi: 10.1002/gepi.20571.
10
Effects of maternal smoking and exposure to methylmercury on brain-derived neurotrophic factor concentrations in umbilical cord serum.母体吸烟和甲基汞暴露对脐带血清中脑源性神经营养因子浓度的影响。
Toxicol Sci. 2010 Oct;117(2):263-9. doi: 10.1093/toxsci/kfq216. Epub 2010 Jul 14.

Genetic susceptibility to methylmercury developmental neurotoxicity matters.

作者信息

Julvez Jordi, Grandjean Philippe

机构信息

Department of Environmental Health, Harvard School of Public Health Boston, MA, USA ; Centre for Research in Environmental Epidemiology Catalonia, Spain.

Department of Environmental Health, Harvard School of Public Health Boston, MA, USA ; Department of Environmental Medicine, University of Southern Denmark Odense, Denmark.

出版信息

Front Genet. 2013 Dec 13;4:278. doi: 10.3389/fgene.2013.00278. eCollection 2013.

DOI:10.3389/fgene.2013.00278
PMID:24379825
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3861742/
Abstract
摘要