多中心性Castleman病与HIV
Multicentric Castleman's disease and HIV.
作者信息
Krause John R, Robinson Sara D, Vance Estil A
机构信息
Department of Pathology, Section of Hematopathology (Krause), and the Department of Hematology/Oncology (Robinson, Vance), Baylor University Medical Center at Dallas and the Baylor Charles A. Sammons Cancer Center at Dallas.
出版信息
Proc (Bayl Univ Med Cent). 2014 Jan;27(1):28-30. doi: 10.1080/08998280.2014.11929044.
Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder found with a higher frequency in HIV-seropositive patients. Human herpes virus 8 is found in virtually all cases of HIV-associated MCD. The majority of cases of MCD in patients with HIV are also associated with Kaposi's sarcoma. The dysregulated production of human IL-6 is thought to be an important factor in the pathogenesis of MCD. HIV-seropositive individuals with MCD have a significantly greater risk of developing non-Hodgkin lymphomas than their HIV-seronegative counterparts. MCD occurring in HIV patients has been associated with a poor prognosis. With newer therapy regimens, it is hoped that the prospects of HIV-infected patients with MCD will improve.
多中心Castleman病（MCD）是一种罕见的淋巴增殖性疾病，在HIV血清阳性患者中发病率较高。几乎所有HIV相关MCD病例中都能发现人类疱疹病毒8。HIV患者中大多数MCD病例也与卡波西肉瘤有关。人类白细胞介素-6的失调产生被认为是MCD发病机制中的一个重要因素。与HIV血清阴性的个体相比，患有MCD的HIV血清阳性个体发生非霍奇金淋巴瘤的风险显著更高。HIV患者中发生的MCD与预后不良有关。随着更新的治疗方案的出现，希望感染HIV且患有MCD的患者的前景会有所改善。
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