Soulier J, Grollet L, Oksenhendler E, Cacoub P, Cazals-Hatem D, Babinet P, d'Agay M F, Clauvel J P, Raphael M, Degos L
Laboratoire d'Hématologie Moléculaire, Hôpital Saint-Louis, Paris, France.
Blood. 1995 Aug 15;86(4):1276-80.
Multicentric Castleman's disease (MCD) is an atypical lymphoproliferative disorder defined using clinical and pathologic criteria. A characteristic of the MCD is a close association with Kaposi's sarcoma (KS), which occurs during the clinical course of most human immunodeficiency virus (HIV)-associated MCD cases and also, but less frequently, in HIV-negative patients. Recently, sequences of a putative new Herpesvirus (KSHV) have been isolated and further detected in almost all the acquired immunodeficiency syndrome (AIDS) KS and in most of the non-AIDS KS samples. In this study, we searched for these Herpesvirus-like sequences in MCD samples of 31 patients. KSHV sequences were detected in 14 of 14 cases of HIV-associated MCD, including 5 cases without detectable KS. Moreover, KSHV was detected in 7 of 17 MCD cases in HIV-negative patients, including 1 case associated with a cutaneous KS. In 34 non-MCD reactive lymph nodes (follicular and/or interfollicular hyperplasia) in HIV-negative patients, KSHV was detected in only 1 case. In 1 HIV-negative case of MCD, KSHV was found in both the lymph node and peripheral blood samples. These data suggest that KSHV could play a role in the pathogenesis of MCD, especially in HIV-infected patients.
多中心性Castleman病（MCD）是一种根据临床和病理标准定义的非典型淋巴增生性疾病。MCD的一个特点是与卡波西肉瘤（KS）密切相关，在大多数人类免疫缺陷病毒（HIV）相关的MCD病例临床过程中会出现KS，在HIV阴性患者中也会出现，但频率较低。最近，一种假定的新型疱疹病毒（KSHV）的序列已被分离出来，并在几乎所有获得性免疫缺陷综合征（AIDS）相关的KS以及大多数非AIDS相关的KS样本中进一步检测到。在本研究中，我们在31例患者的MCD样本中寻找这些类疱疹病毒序列。在14例HIV相关的MCD病例中的14例检测到KSHV序列，包括5例未检测到KS的病例。此外，在17例HIV阴性患者的MCD病例中的7例检测到KSHV，包括1例与皮肤KS相关的病例。在34例HIV阴性患者的非MCD反应性淋巴结（滤泡和/或滤泡间增生）中，仅1例检测到KSHV。在1例HIV阴性的MCD病例中，在淋巴结和外周血样本中均发现了KSHV。这些数据表明KSHV可能在MCD的发病机制中起作用，尤其是在HIV感染患者中。
