Antonicek H, Persohn E, Schachner M
J Cell Biol. 1987 Jun;104(6):1587-95. doi: 10.1083/jcb.104.6.1587.
Adhesion molecule on glia (AMOG) is a novel neural cell adhesion molecule that mediates neuron-astrocyte interaction in vitro. In situ AMOG is expressed in the cerebellum by glial cells at the critical developmental stages of granule neuron migration. Granule neuron migration that is guided by surface contacts between migrating neurons and astroglial processes is inhibited by monoclonal AMOG antibody, probably by disturbing neuron-glia adhesion. AMOG is an integral cell surface glycoprotein of 45-50-kD molecular weight with a carbohydrate content of at least 30%. It does not belong to the L2/HNK-1 family of neural cell adhesion molecules but expresses another carbohydrate epitope that is shared with the adhesion molecules L1 and myelin-associated glycoprotein, but is not present on N-CAM or J1.
神经胶质细胞黏附分子(AMOG)是一种新型神经细胞黏附分子,可在体外介导神经元与星形胶质细胞的相互作用。在原位,AMOG在颗粒神经元迁移的关键发育阶段由小脑的神经胶质细胞表达。由迁移神经元与星形胶质细胞突起之间的表面接触引导的颗粒神经元迁移受到单克隆AMOG抗体的抑制,这可能是通过干扰神经元与神经胶质细胞的黏附来实现的。AMOG是一种分子量为45 - 50 kD的完整细胞表面糖蛋白,碳水化合物含量至少为30%。它不属于神经细胞黏附分子的L2/HNK - 1家族,但表达另一种碳水化合物表位,该表位与黏附分子L1和髓鞘相关糖蛋白共有,但不存在于N - CAM或J1上。