Walden J, Dietrich L H, Speckmann E J
Neurosci Lett. 1987 Apr 23;76(1):53-7. doi: 10.1016/0304-3940(87)90191-1.
Intracellular Ca2+ is known to activate an early unspecific inward and a potassium outward current in various vertebrate and invertebrate preparations. In the identified neurons B1, B2 and B3 of the buccal ganglia of Helix pomatia an intracellular application of Ca2+ induced a late long-lasting inward current besides the currents mentioned. Ca2+ was injected by ionophoresis or pressure pulses. The long-lasting inward current was reversed at membrane potentials of between -30 and -40 mV, whereas the equilibrium potential of the unspecific inward and potassium outward current was in the range of -20 to +10 mV and -50 to -70 mV, respectively. The late inward current was accompanied by an increase of the membrane conductance and suppressed by the Cl- channel blocker 9-anthracencarbonic acid. The equilibrium potential shifted with changes in the extracellular Cl- concentration. The long-lasting inward current is suggested to be activated by intracellular Ca2+ and to be carried by Cl-.
已知细胞内钙离子能在各种脊椎动物和无脊椎动物标本中激活早期非特异性内向电流和钾外向电流。在罗马蜗牛颊神经节中已鉴定出的B1、B2和B3神经元，除上述电流外，细胞内施加钙离子还会诱发晚期持久内向电流。通过离子电泳或压力脉冲注入钙离子。持久内向电流在膜电位-30至-40 mV之间反转，而非特异性内向电流和钾外向电流的平衡电位分别在-20至+10 mV和-50至-70 mV范围内。晚期内向电流伴随着膜电导增加，并被氯离子通道阻滞剂9-蒽甲酸抑制。平衡电位随细胞外氯离子浓度变化而移动。推测持久内向电流由细胞内钙离子激活，并由氯离子携带。
