Högstorp H, Carlin G
Ups J Med Sci. 1987;92(1):79-83. doi: 10.3109/03009738709178681.
The plasminogen-binding (PB-AP) and non-plasminogen-binding (NPB-AP) forms of alpha 2-antiplasmin (AP), were assayed in rat plasma by a modified rocket immunoelectrophoretic technique before and up to 48 h after turpentine-induced trauma, using an intermediary gel containing kringles 1-3 from plasminogen. The concentration of PB-AP was significantly elevated by 22% 24 h post-traumatically, while NPB-AP was decreased at that point in time, leaving the total AP level unchanged. Total AP increased by 57% during the period 24-48 h after trauma, mainly on account of increases in the NPB-AP form. It is concluded that the plasma level of AP can remain unchanged in spite of increased fibrinolysis inhibition, owing to a relative increase in the functionally more active PB-AP.
采用改良的火箭免疫电泳技术，利用含有纤溶酶原kringles 1-3的中间凝胶，在松节油诱导创伤前后及创伤后48小时内，对大鼠血浆中的α2-抗纤溶酶（AP）的纤溶酶原结合形式（PB-AP）和非纤溶酶原结合形式（NPB-AP）进行检测。创伤后24小时，PB-AP浓度显著升高22%，而此时NPB-AP浓度降低，总AP水平保持不变。创伤后24 - 48小时内，总AP增加了57%，主要是由于NPB-AP形式增加。得出结论：尽管纤维蛋白溶解抑制增加，但由于功能上更活跃的PB-AP相对增加，AP的血浆水平仍可保持不变。
