Rodrigues M M, Krachmer J H, Sun T T
Trans Am Ophthalmol Soc. 1986;84:146-69.
Epithelial downgrowth developed in three patients following cataract extraction and keratoplasty. Light and electron microscopy of the downgrowth tissue disclosed stratified squamous epithelium, but could not determine whether they were derived from conjunctival or corneal epithelium. The epithelial downgrowth contained cells that were connected laterally by desmosomal junctions and displayed well-defined basement membranes. Surface epithelial cells exhibited myriad microvillous processes scant to moderate mitochondria. In one case, prominent hemidesmosomal junctions were present. Immunohistochemical staining with monoclonal antikeratin antibodies revealed immunoreactivity with AE1, AE3, and AE11 in all cases, but with a cornea-specific antibody, AE5, in only one case. We concluded that in this last case, the epithelial downgrowth appears to have originated from the corneal epithelium.
三名患者在白内障摘除和角膜移植术后发生了上皮内生。对内生组织进行光镜和电镜检查发现为复层鳞状上皮，但无法确定其是来源于结膜上皮还是角膜上皮。上皮内生组织中的细胞通过桥粒连接侧向相连，并可见明确的基底膜。表面上皮细胞有大量微绒毛突起，线粒体稀少至中等数量。在1例中，可见明显的半桥粒连接。用单克隆抗角蛋白抗体进行免疫组化染色，所有病例均显示与AE1、AE3和AE11有免疫反应，但仅1例与角膜特异性抗体AE5有免疫反应。我们得出结论，在最后这例病例中，上皮内生似乎起源于角膜上皮。
