Suppr超能文献

法国是如何启动其心脏死亡后器官捐赠项目的。

How France launched its donation after cardiac death program.

作者信息

Antoine C, Mourey F, Prada-Bordenave E

机构信息

Agence de la biomédecine, direction générale médicale et scientifique, direction prélèvement greffe organes-tissus, pôle stratégie prélèvement greffe, 1, avenue du Stade-de-France, 93212 Saint-Denis-la-Plaine cedex, France.

Agence de la biomédecine, direction générale médicale et scientifique, direction prélèvement greffe organes-tissus, SRA Sud-Est/Océan Indien, bâtiment B, 162, avenue Lacassagne, 69424 Lyon cedex 03, France.

出版信息

Ann Fr Anesth Reanim. 2014 Feb;33(2):138-43. doi: 10.1016/j.annfar.2013.11.018. Epub 2013 Dec 30.

Abstract

On the basis of the literature and results presented at the 6th International Conference, donation after cardio-circulatory death provides a significant, practical, additional high quality source of transplantable organs. The vast majority of DCD are 'controlled' Maastricht category III donors. In 2010, the parliamentary information mission on the revision of the bioethics laws invited the Intensive Care Societies to debate and to make recommendations to implement controlled donation after circulatory death. They came to the conclusion that such retrieval is possible in France and insisted on the medical criteria that frame it: the writing of the medical procedures, the ethical aspects and the delay. The major recommendations of the ethics committees were firstly, The WLST decision is independent of the possibility of organ donation; secondly, the strict respect of "The dead donor and organ transplantation rule" and the updated national guidance for the WLST; thirdly, the drafting of a nationally agreed protocol defining the mandatory conditions to determine death and to perform procurement and transplantation. Organ donation after WLST will be authorised only in pilot centres with a locally agreed WLST policy including external second opinion and written transcript of the WLST decision, experienced intensive care staff, a local organ procurement coordination team familiar with DBD and DCD protocols and only in hospitals authorised for organ procurement. It is important to have an optimal and standardized national guidance to limit the known risk factors of graft failure (donor and recipient choice, warm and cold ischemia time), to increase acceptance by medical community and civil society and to improve results and allow more powerful analysis.

摘要

基于第六届国际会议上发表的文献和研究结果,心源性循环死亡后的器官捐献提供了一个重要、实用且高质量的可移植器官额外来源。绝大多数心源性循环死亡后的器官捐献者属于“可控的”马斯特里赫特分类III类捐献者。2010年,关于生物伦理法修订的议会信息调查团邀请重症监护协会进行辩论,并就实施心源性循环死亡后的可控器官捐献提出建议。他们得出结论,在法国这种器官获取是可行的,并强调了对此进行规范的医学标准:医疗程序的制定、伦理方面以及时间间隔。伦理委员会的主要建议如下:首先,脑死亡判定的决定独立于器官捐献的可能性;其次,严格遵守“死亡捐献者与器官移植规则”以及最新的国家脑死亡判定指南;第三,起草一份全国统一的协议,明确确定死亡以及进行获取和移植的强制性条件。仅在具有当地商定的脑死亡判定政策(包括外部二次意见和脑死亡判定决定的书面记录)、经验丰富的重症监护人员、熟悉脑死亡判定和心源性循环死亡后器官捐献协议的当地器官获取协调团队,且仅在获得器官获取授权的医院的试点中心,才会批准脑死亡判定后的器官捐献。拥有最优且标准化的国家指南很重要,以限制已知的移植失败风险因素(供体和受体的选择、热缺血和冷缺血时间),提高医学界和民间社会的接受度,并改善结果,进而进行更有力的分析。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验