Van der Velden S K, Shadid N H, Nelemans P J, Sommer A
Department of Dermatology, Erasmus Universal Centre, Rotterdam, The Netherlands
Department of Dermatology, Medical Centre Haaglanden, Den Haag, The Netherlands.
Phlebology. 2014 Oct;29(9):580-6. doi: 10.1177/0268355513515859. Epub 2014 Jan 3.
The objective of this study is to evaluate whether and which 'venous' symptoms are characteristic for patients affected with chronic venous disease compared to patients with other diseases of the lower limbs (e.g. arthrosis, peripheral arterial disease, spinal disc herniation).
A cross-sectional study was performed to compare the frequency of venous symptoms among 76 patients with chronic venous disease and reflux and 74 patients with other diseases of the legs without reflux. The VEINES-Sym of the VEINES-QOL/Sym questionnaire was used to evaluate the frequency of symptoms. Demographic, clinical classification and ultrasound findings were also noted.
A total of 122 patients were included for analysis (response rate of 87%). Presence of venous symptoms was slightly more often reported in the chronic venous disease group than in the non-chronic venous disease group, but differences were small and statistically non-significant. Severity of chronic venous disease as classified by the CEAP classification was not associated with higher proportions of patients reporting symptoms than in non-chronic venous disease patients, except for swelling (p = .016) and itching (p = .007) in C3-C6 patients. The largest difference between the chronic venous disease and non-chronic venous disease group was observed for the time of the day at which symptoms were most intense; patients with chronic venous disease were more likely to experience symptoms at the end of the day (p < .001).
The small differences in prevalence of reported 'venous' symptoms between chronic venous disease patients and patients with other diseases of the legs suggest that these symptoms may be less specific for patients with chronic venous disease and refluxing veins than is usually assumed.
本研究的目的是评估与患有其他下肢疾病（如关节炎、外周动脉疾病、腰椎间盘突出症）的患者相比，慢性静脉疾病患者是否以及哪些“静脉”症状具有特征性。
进行一项横断面研究，比较76例患有慢性静脉疾病并伴有反流的患者与74例患有其他无反流腿部疾病的患者的静脉症状发生频率。使用静脉症状生活质量/症状问卷（VEINES-QOL/Sym）中的静脉症状（VEINES-Sym）部分来评估症状发生频率。还记录了人口统计学、临床分类和超声检查结果。
共有122例患者纳入分析（应答率为87%）。慢性静脉疾病组报告有静脉症状的情况略多于非慢性静脉疾病组，但差异较小且无统计学意义。除了C3 - C6患者的肿胀（p = 0.016）和瘙痒（p = 0.007）外，慢性静脉疾病按CEAP分类的严重程度与报告有症状的患者比例高于非慢性静脉疾病患者无关。慢性静脉疾病组和非慢性静脉疾病组之间在症状最严重的一天中的时间差异最大；慢性静脉疾病患者在一天结束时更有可能出现症状（p < 0.001）。
慢性静脉疾病患者与腿部患有其他疾病的患者在报告的“静脉”症状患病率上的微小差异表明，这些症状对于慢性静脉疾病和静脉反流患者而言，可能不像通常所认为的那样具有特异性。
